Skip to main content

Table 4 Characteristics of common drug-drug interactions

From: Epidemiology of potential drug-drug interactions in elderly population admitted to critical care units of Peshawar, Pakistan

Drug combination Frequency Severity Documentation Potential outcome Mechanism Management
Aspirin & clopidogrel 420 Major Fair Increased risk of bleeding Synergism Monitor blood count
Clopidogrel & Enoxaparin 277 Major Fair Increased risk of bleeding Synergism Monitor blood count
Aspirin & Ramipril 186 Moderate Fair Decreased Ramipril effectiveness Inhibition of prostaglandin synthesis Replace Ramipril with suitable drug
Aspirin & Diuretics 239 Major Good Reduced diuretic effectiveness and risk of nephrotoxicity Decreased renal prostaglandin synthesis Monitor for any changes
Aspirin & Betablockers 251 Moderate Good Antihypertensive effect of beta blockers may be reduced Decreased renal prostaglandin synthesis Monitor for any changes
Aspirin & Nitroglycerin 156 Moderate Good Increased nitroglycerin plasma concentration Synergism Monitor for any changes
Clopidogrel & Atorvastatin 97 Moderate Excellent Decreased formation of clopidogrel active metabolite Competition with CYP3A4 Replace with rosuvastatin or pravastatin
Ramipril & Furosemide 69 Moderate Good Postural hypotension Vasodilation Monitor for any changes
Aspirin & Ranitidine 59 Minor Excellent Decreased plasma levels of aspirin Reduced absorption of aspirin Monitor for any changes
Clopidogrel & Omeprazole 37 Major Excellent Decreased plasma concentration of clopidogrel Inhibition of CYP2C19 mediated clopidogrel metabolism. Use pantoprazole instead of omeprazole
Dexamethasone & Nimodipine 33 Major Fair Decreased plasma concentration of nimodipine Induction of CYP3A4 mediated metabolism of nimodipine Replace with suitable drug