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Table 1 Mean pharmacokinetic parameters obtained from 23 volunteers after administration of each Silybin formulation

From: Superior silybin bioavailability of silybin–phosphatidylcholine complex in oily-medium soft-gel capsules versus conventional silymarin tablets in healthy volunteers*

  SPC soft-gel capsule Mean ± SE SM tablets Mean ± SE P
Tmax (h) 1.1 ± 0.7 1.9 ± 0.9 <  0.0001
Cmax (ng/mL) 207.1 ± 62.4 12.6 ± 31.4 <  0.0001
AUC0–T (ng/h/mL) 302.6 ± 126.6 26.4 ± 56.7 <  0.0001
AUC0–∞ (ng/h/mL) 308.8 ± 126.1 29.5 ± 14.1 <  0.0001
t½ (h) 1.4 ± 0.5 4.6 ± 5.8 <  0.0001