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Table 1 Mean pharmacokinetic parameters obtained from 23 volunteers after administration of each Silybin formulation

From: Superior silybin bioavailability of silybin–phosphatidylcholine complex in oily-medium soft-gel capsules versus conventional silymarin tablets in healthy volunteers*

 

SPC soft-gel capsule Mean ± SE

SM tablets Mean ± SE

P

Tmax (h)

1.1 ± 0.7

1.9 ± 0.9

<  0.0001

Cmax (ng/mL)

207.1 ± 62.4

12.6 ± 31.4

<  0.0001

AUC0–T (ng/h/mL)

302.6 ± 126.6

26.4 ± 56.7

<  0.0001

AUC0–∞ (ng/h/mL)

308.8 ± 126.1

29.5 ± 14.1

<  0.0001

t½ (h)

1.4 ± 0.5

4.6 ± 5.8

<  0.0001