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Table 1 Characteristics of epilepsy outpatients with and without ADRs (total = 3069)

From: Adverse drug reactions associated with six commonly used antiepileptic drugs in southern China from 2003 to 2015

Variable

Epilepsy outpatients with ADRs (N = 1807)

Epilepsy outpatients without ADRs (N = 1262)

p-value

Age at last visit, years (n, %)

  

0.156a

  ≤ 12

395 (21.9)

287 (22.7)

 

 13–18

499 (27.6)

323 (25.6)

 

 19–45

783 (43.3)

536 (42.5)

 

  > 45

130 (7.2)

116 (9.2)

 

Age at epilepsy diagnosis, years (median, (range))

18.2 (0.17–86.0)

18.3 (0.1–81.3)

0.770b

Sex (n, %)

  

<  0.001a

 Female

893 (49.4)

491 (38.9)

 

 Male

914 (50.6)

771 (61.1)

 

Comorbidity (n, %)

  

<  0.001a

 Yes

374 (20.7)

180 (14.3)

 

 No

1433 (79.3)

1082 (85.7)

 

Number of AEDs received (n, %)c

 

<  0.001a

 One

489 (27.1)

756 (59.9)

 

 Two

645 (35.7)

371 (29.4)

 

 Three+

673 (37.2)

135 (10.7)

 
  1. ADRs adverse drug reactions, AEDs antiepileptic drugs
  2. aPearson chi-square test
  3. bMann-Whitney U test
  4. cMultiple comparison, p = 0.05/3 = 0.0167 after Bonferroni correction. Two vs. one p <  0.001; three+ vs. one p <  0.001; three+ vs. two p <  0.001