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Table 1 Characteristics of epilepsy outpatients with and without ADRs (total = 3069)

From: Adverse drug reactions associated with six commonly used antiepileptic drugs in southern China from 2003 to 2015

Variable Epilepsy outpatients with ADRs (N = 1807) Epilepsy outpatients without ADRs (N = 1262) p-value
Age at last visit, years (n, %)    0.156a
  ≤ 12 395 (21.9) 287 (22.7)  
 13–18 499 (27.6) 323 (25.6)  
 19–45 783 (43.3) 536 (42.5)  
  > 45 130 (7.2) 116 (9.2)  
Age at epilepsy diagnosis, years (median, (range)) 18.2 (0.17–86.0) 18.3 (0.1–81.3) 0.770b
Sex (n, %)    <  0.001a
 Female 893 (49.4) 491 (38.9)  
 Male 914 (50.6) 771 (61.1)  
Comorbidity (n, %)    <  0.001a
 Yes 374 (20.7) 180 (14.3)  
 No 1433 (79.3) 1082 (85.7)  
Number of AEDs received (n, %)c   <  0.001a
 One 489 (27.1) 756 (59.9)  
 Two 645 (35.7) 371 (29.4)  
 Three+ 673 (37.2) 135 (10.7)  
  1. ADRs adverse drug reactions, AEDs antiepileptic drugs
  2. aPearson chi-square test
  3. bMann-Whitney U test
  4. cMultiple comparison, p = 0.05/3 = 0.0167 after Bonferroni correction. Two vs. one p <  0.001; three+ vs. one p <  0.001; three+ vs. two p <  0.001