Adverse drug reactions associated with six commonly used antiepileptic drugs in southern China from 2003 to 2015

Table 1 Characteristics of epilepsy outpatients with and without ADRs (total = 3069)

Variable	Epilepsy outpatients with ADRs (N = 1807)	Epilepsy outpatients without ADRs (N = 1262)	p-value
Age at last visit, years (n, %)			0.156^a
≤ 12	395 (21.9)	287 (22.7)
13–18	499 (27.6)	323 (25.6)
19–45	783 (43.3)	536 (42.5)
> 45	130 (7.2)	116 (9.2)
Age at epilepsy diagnosis, years (median, (range))	18.2 (0.17–86.0)	18.3 (0.1–81.3)	0.770^b
Sex (n, %)			< 0.001^a
Female	893 (49.4)	491 (38.9)
Male	914 (50.6)	771 (61.1)
Comorbidity (n, %)			< 0.001^a
Yes	374 (20.7)	180 (14.3)
No	1433 (79.3)	1082 (85.7)
Number of AEDs received (n, %)^c			< 0.001^a
One	489 (27.1)	756 (59.9)
Two	645 (35.7)	371 (29.4)
Three+	673 (37.2)	135 (10.7)

ADRs adverse drug reactions, AEDs antiepileptic drugs
^aPearson chi-square test
^bMann-Whitney U test
^cMultiple comparison, p = 0.05/3 = 0.0167 after Bonferroni correction. Two vs. one p < 0.001; three+ vs. one p < 0.001; three+ vs. two p < 0.001

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