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Table 3 Number of adverse drug reactions and severe adverse reactions stratified by system organ class

From: Adverse drug reactions associated with six commonly used antiepileptic drugs in southern China from 2003 to 2015

System organ class (descending order) All Number of AEDs related to the ADR
One AEDs Two AEDs More than three AEDs
Number (severea) Number (severea) Number (severea) Number (severea)
Psychiatric disorders 1633 (84) 813 (29) 710 (39) 110 (16)
Neurological disorders 1222 (93) 630 (46) 500 (37) 92 (10)
Gastrointestinal disorders 564 (68) 244 (26) 280 (31) 40 (11)
Skin and appendage disorders 341 (131) 183 (67) 132 (50) 26 (14)
Body as a whole - general disorders 260 (19) 137 (10) 108 (5) 15 (4)
Metabolic and nutritional disorders 257 (19) 131 (8) 107 (8) 19 (3)
Liver and biliary disorders 236 (33) 135 (17) 84 (12) 17 (4)
Vision disorders 88 (6) 28 (2) 45 (3) 15 (1)
Reproductive disorders 88 (16) 48 (9) 36 (4) 4 (3)
Blood disorders 81 (25) 32 (15) 37 (9) 12 (1)
Musculoskeletal disorders 65 (11) 39 (5) 23 (4) 3 (2)
Urinary tract disorders 55 (9) 30 (5) 23 (3) 2 (1)
Hearing, vestibular and special senses disorders 49 (2) 32 (1) 16 (1) 1 (0)
Cardiovascular disorders 42 (2) 26 (2) 13 (0) 3 (0)
Vascular, bleeding and clotting disorders 36 (2) 19 (1) 16 (1) 1 (0)
Respiratory disorders 15 (4) 9 (1) 4 (2) 2 (1)
Immune disorders and infections 13 (9) 8 (6) 4 (3) 1 (0)
Congenital disorders 4 (4) 2 (2) 2 (2) 0 (0)
Total 5049 (537) 2546 (252) 2140 (214) 363 (71)
  1. ADRs adverse drug reactions, AEDs antiepileptic drugs, SARs severe adverse reactions
  2. aSARs refers to those ADRs requiring withdrawal of the suspected drugs and symptomatic treatment, regardless of whether the suspected drugs were used in mono- or polytherapy