TY - JOUR AU - Millan, M. J. AU - Andrieux, A. AU - Bartzokis, G. AU - Cadenhead, K. AU - Dazzan, P. AU - Fusar-Poli, P. AU - Gallinat, J. AU - Giedd, J. AU - Grayson, D. R. AU - Heinrichs, M. PY - 2016 DA - 2016// TI - Altering the course of schizophrenia: progress and perspectives JO - Nat Rev Drug Discov VL - 15 UR - https://doi.org/10.1038/nrd.2016.28 DO - 10.1038/nrd.2016.28 ID - Millan2016 ER - TY - STD TI - Ibi D, de la Fuente Revenga M, Kezunovic N, Muguruza C, Saunders JM, Gaitonde SA, Moreno JL, Ijaz MK, Santosh V, Kozlenkov A, et al. Antipsychotic-induced Hdac2 transcription via NF-kappaB leads to synaptic and cognitive side effects. Nat Neurosci. 2017;20(9):1247–1259. ID - ref2 ER - TY - JOUR AU - Owen, M. J. AU - Sawa, A. AU - Mortensen, P. B. PY - 2016 DA - 2016// TI - Schizophrenia JO - Lancet VL - 388 UR - https://doi.org/10.1016/S0140-6736(15)01121-6 DO - 10.1016/S0140-6736(15)01121-6 ID - Owen2016 ER - TY - JOUR AU - Meltzer, H. Y. PY - 2013 DA - 2013// TI - Update on typical and atypical antipsychotic drugs JO - Annu Rev Med VL - 64 UR - https://doi.org/10.1146/annurev-med-050911-161504 DO - 10.1146/annurev-med-050911-161504 ID - Meltzer2013 ER - TY - JOUR AU - Leucht, S. AU - Cipriani, A. AU - Spineli, L. AU - Mavridis, D. AU - Orey, D. AU - Richter, F. AU - Samara, M. AU - Barbui, C. AU - Engel, R. R. AU - Geddes, J. R. PY - 2013 DA - 2013// TI - Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis JO - Lancet VL - 382 UR - https://doi.org/10.1016/S0140-6736(13)60733-3 DO - 10.1016/S0140-6736(13)60733-3 ID - Leucht2013 ER - TY - JOUR AU - Musil, R. AU - Obermeier, M. AU - Russ, P. AU - Hamerle, M. PY - 2015 DA - 2015// TI - Weight gain and antipsychotics: a drug safety review JO - Expert Opin Drug Saf VL - 14 UR - https://doi.org/10.1517/14740338.2015.974549 DO - 10.1517/14740338.2015.974549 ID - Musil2015 ER - TY - JOUR AU - Ferno, J. AU - Ersland, K. M. AU - Duus, I. H. AU - Gonzalez-Garcia, I. AU - Fossan, K. O. AU - Berge, R. K. AU - Steen, V. M. AU - Skrede, S. PY - 2015 DA - 2015// TI - Olanzapine depot exposure in male rats: dose-dependent lipogenic effects without concomitant weight gain JO - Eur Neuropsychopharmacol VL - 25 UR - https://doi.org/10.1016/j.euroneuro.2015.03.002 DO - 10.1016/j.euroneuro.2015.03.002 ID - Ferno2015 ER - TY - JOUR AU - Orsolini, L. AU - Tomasetti, C. AU - Valchera, A. AU - Vecchiotti, R. AU - Matarazzo, I. AU - Vellante, F. AU - Iasevoli, F. AU - Buonaguro, E. F. AU - Fornaro, M. AU - Fiengo, A. L. PY - 2016 DA - 2016// TI - An update of safety of clinically used atypical antipsychotics JO - Expert Opin Drug Saf VL - 15 UR - https://doi.org/10.1080/14740338.2016.1201475 DO - 10.1080/14740338.2016.1201475 ID - Orsolini2016 ER - TY - JOUR AU - Rojo, L. E. AU - Gaspar, P. A. AU - Silva, H. AU - Risco, L. AU - Arena, P. AU - Cubillos-Robles, K. AU - Jara, B. PY - 2015 DA - 2015// TI - Metabolic syndrome and obesity among users of second generation antipsychotics: a global challenge for modern psychopharmacology JO - Pharmacol Res VL - 101 UR - https://doi.org/10.1016/j.phrs.2015.07.022 DO - 10.1016/j.phrs.2015.07.022 ID - Rojo2015 ER - TY - JOUR AU - Zhang, B. AU - Deng, L. AU - Wu, H. AU - Lu, X. AU - Peng, L. AU - Wu, R. AU - Guo, W. AU - Chen, J. AU - Li, L. AU - Zhao, J. PY - 2016 DA - 2016// TI - Relationship between long-term use of a typical antipsychotic medication by Chinese schizophrenia patients and the bone turnover markers serum osteocalcin and beta-CrossLaps JO - Schizophr Res VL - 176 UR - https://doi.org/10.1016/j.schres.2016.06.034 DO - 10.1016/j.schres.2016.06.034 ID - Zhang2016 ER - TY - JOUR AU - Stubbs, B. AU - Gaughran, F. AU - Mitchell, A. J. AU - Hert, M. AU - Farmer, R. AU - Soundy, A. AU - Rosenbaum, S. AU - Vancampfort, D. PY - 2015 DA - 2015// TI - Schizophrenia and the risk of fractures: a systematic review and comparative meta-analysis JO - Gen Hosp Psychiatry VL - 37 UR - https://doi.org/10.1016/j.genhosppsych.2015.01.004 DO - 10.1016/j.genhosppsych.2015.01.004 ID - Stubbs2015 ER - TY - JOUR AU - Holt, R. I. PY - 2010 DA - 2010// TI - Osteoporosis in people with severe mental illness: a forgotten condition JO - Maturitas VL - 67 UR - https://doi.org/10.1016/j.maturitas.2010.06.004 DO - 10.1016/j.maturitas.2010.06.004 ID - Holt2010 ER - TY - JOUR AU - Bernabei, R. AU - Martone, A. M. AU - Ortolani, E. AU - Landi, F. AU - Marzetti, E. PY - 2014 DA - 2014// TI - Screening, diagnosis and treatment of osteoporosis: a brief review JO - Clin Cases Miner Bone Metab VL - 11 ID - Bernabei2014 ER - TY - JOUR AU - Harada, S. AU - Rodan, G. A. PY - 2003 DA - 2003// TI - Control of osteoblast function and regulation of bone mass JO - Nature VL - 423 UR - https://doi.org/10.1038/nature01660 DO - 10.1038/nature01660 ID - Harada2003 ER - TY - JOUR AU - Long, F. PY - 2011 DA - 2011// TI - Building strong bones: molecular regulation of the osteoblast lineage JO - Nat Rev Mol Cell Biol VL - 13 UR - https://doi.org/10.1038/nrm3254 DO - 10.1038/nrm3254 ID - Long2011 ER - TY - JOUR AU - Baron, R. AU - Kneissel, M. PY - 2013 DA - 2013// TI - WNT signaling in bone homeostasis and disease: from human mutations to treatments JO - Nat Med VL - 19 UR - https://doi.org/10.1038/nm.3074 DO - 10.1038/nm.3074 ID - Baron2013 ER - TY - JOUR AU - Kahn, M. PY - 2014 DA - 2014// TI - Can we safely target the WNT pathway? JO - Nat Rev Drug Discov VL - 13 UR - https://doi.org/10.1038/nrd4233 DO - 10.1038/nrd4233 ID - Kahn2014 ER - TY - JOUR AU - Shan, T. AU - Zhou, C. AU - Yang, R. AU - Yan, F. AU - Zhang, P. AU - Fu, Y. AU - Jiang, H. PY - 2015 DA - 2015// TI - Lithium chloride promotes the odontoblast differentiation of hair follicle neural crest cells by activating Wnt/beta-catenin signaling JO - Cell Biol Int VL - 39 UR - https://doi.org/10.1002/cbin.10340 DO - 10.1002/cbin.10340 ID - Shan2015 ER - TY - JOUR AU - Wang, H. D. AU - Shi, Y. M. AU - Li, L. AU - Guo, J. D. AU - Zhang, Y. P. AU - Hou, S. X. PY - 2013 DA - 2013// TI - Treatment with resveratrol attenuates sublesional bone loss in spinal cord-injured rats JO - Br J Pharmacol VL - 170 UR - https://doi.org/10.1111/bph.12301 DO - 10.1111/bph.12301 ID - Wang2013 ER - TY - JOUR AU - Feng, G. AU - Zheng, K. AU - Song, D. AU - Xu, K. AU - Huang, D. AU - Zhang, Y. AU - Cao, P. AU - Shen, S. AU - Zhang, J. AU - Feng, X. PY - 2016 DA - 2016// TI - SIRT1 was involved in TNF-alpha-promoted osteogenic differentiation of human DPSCs through Wnt/beta-catenin signal JO - In Vitro Cell Dev Biol Anim VL - 52 UR - https://doi.org/10.1007/s11626-016-0070-9 DO - 10.1007/s11626-016-0070-9 ID - Feng2016 ER - TY - JOUR AU - Abed, E. AU - Couchourel, D. AU - Delalandre, A. AU - Duval, N. AU - Pelletier, J. P. AU - Martel-Pelletier, J. AU - Lajeunesse, D. PY - 2014 DA - 2014// TI - Low sirtuin 1 levels in human osteoarthritis subchondral osteoblasts lead to abnormal sclerostin expression which decreases Wnt/beta-catenin activity JO - Bone VL - 59 UR - https://doi.org/10.1016/j.bone.2013.10.020 DO - 10.1016/j.bone.2013.10.020 ID - Abed2014 ER - TY - JOUR AU - Hert, M. AU - Detraux, J. AU - Stubbs, B. PY - 2016 DA - 2016// TI - Relationship between antipsychotic medication, serum prolactin levels and osteoporosis/osteoporotic fractures in patients with schizophrenia: a critical literature review JO - Expert Opin Drug Saf VL - 15 UR - https://doi.org/10.1517/14740338.2016.1167873 DO - 10.1517/14740338.2016.1167873 ID - Hert2016 ER - TY - JOUR AU - Howes, O. D. AU - Wheeler, M. J. AU - Meaney, A. M. AU - O'Keane, V. AU - Fogelman, I. AU - Blake, G. AU - Murray, R. M. AU - Smith, S. PY - 2005 DA - 2005// TI - Bone mineral density and its relationship to prolactin levels in patients taking antipsychotic treatment JO - J Clin Psychopharmacol VL - 25 UR - https://doi.org/10.1097/01.jcp.0000162798.87249.4d DO - 10.1097/01.jcp.0000162798.87249.4d ID - Howes2005 ER - TY - JOUR AU - Costa, J. L. AU - Smith, G. AU - Watson, M. AU - Lin, J. M. AU - Callon, K. AU - Gamble, G. AU - Cheng, A. AU - Vickers, M. H. AU - Shepherd, P. R. AU - Cornish, J. PY - 2011 DA - 2011// TI - The atypical anti-psychotic clozapine decreases bone mass in rats in vivo JO - Schizophr Res VL - 126 UR - https://doi.org/10.1016/j.schres.2010.11.024 DO - 10.1016/j.schres.2010.11.024 ID - Costa2011 ER - TY - JOUR AU - Motyl, K. J. AU - Beauchemin, M. AU - Barlow, D. AU - Le, P. T. AU - Nagano, K. AU - Treyball, A. AU - Contractor, A. AU - Baron, R. AU - Rosen, C. J. AU - Houseknecht, K. L. PY - 2017 DA - 2017// TI - A novel role for dopamine signaling in the pathogenesis of bone loss from the atypical antipsychotic drug risperidone in female mice JO - Bone VL - 103 UR - https://doi.org/10.1016/j.bone.2017.07.008 DO - 10.1016/j.bone.2017.07.008 ID - Motyl2017 ER - TY - JOUR AU - Motyl, K. J. AU - DeMambro, V. E. AU - Barlow, D. AU - Olshan, D. AU - Nagano, K. AU - Baron, R. AU - Rosen, C. J. AU - Houseknecht, K. L. PY - 2015 DA - 2015// TI - Propranolol attenuates risperidone-induced trabecular bone loss in female mice JO - Endocrinology VL - 156 UR - https://doi.org/10.1210/en.2015-1099 DO - 10.1210/en.2015-1099 ID - Motyl2015 ER - TY - JOUR AU - Shamas-Din, A. AU - Brahmbhatt, H. AU - Leber, B. AU - Andrews, D. W. PY - 2011 DA - 2011// TI - BH3-only proteins: orchestrators of apoptosis JO - Biochim Biophys Acta VL - 1813 UR - https://doi.org/10.1016/j.bbamcr.2010.11.024 DO - 10.1016/j.bbamcr.2010.11.024 ID - Shamas-Din2011 ER - TY - JOUR AU - Czabotar, P. E. AU - Lessene, G. AU - Strasser, A. AU - Adams, J. M. PY - 2014 DA - 2014// TI - Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy JO - Nat Rev Mol Cell Biol VL - 15 UR - https://doi.org/10.1038/nrm3722 DO - 10.1038/nrm3722 ID - Czabotar2014 ER - TY - JOUR AU - Ashkenazi, A. AU - Fairbrother, W. J. AU - Leverson, J. D. AU - Souers, A. J. PY - 2017 DA - 2017// TI - From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors JO - Nat Rev Drug Discov VL - 16 UR - https://doi.org/10.1038/nrd.2016.253 DO - 10.1038/nrd.2016.253 ID - Ashkenazi2017 ER - TY - JOUR AU - White, M. J. AU - McArthur, K. AU - Metcalf, D. AU - Lane, R. M. AU - Cambier, J. C. AU - Herold, M. J. AU - Delft, M. F. AU - Bedoui, S. AU - Lessene, G. AU - Ritchie, M. E. PY - 2014 DA - 2014// TI - Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production JO - Cell VL - 159 UR - https://doi.org/10.1016/j.cell.2014.11.036 DO - 10.1016/j.cell.2014.11.036 ID - White2014 ER - TY - JOUR AU - Bender, C. E. AU - Fitzgerald, P. AU - Tait, S. W. AU - Llambi, F. AU - McStay, G. P. AU - Tupper, D. O. AU - Pellettieri, J. AU - Sanchez Alvarado, A. AU - Salvesen, G. S. AU - Green, D. R. PY - 2012 DA - 2012// TI - Mitochondrial pathway of apoptosis is ancestral in metazoans JO - Proc Natl Acad Sci U S A VL - 109 UR - https://doi.org/10.1073/pnas.1120680109 DO - 10.1073/pnas.1120680109 ID - Bender2012 ER - TY - JOUR AU - Kim, H. Y. AU - Yoon, J. Y. AU - Yun, J. H. AU - Cho, K. W. AU - Lee, S. H. AU - Rhee, Y. M. AU - Jung, H. S. AU - Lim, H. J. AU - Lee, H. AU - Choi, J. PY - 2015 DA - 2015// TI - CXXC5 is a negative-feedback regulator of the Wnt/beta-catenin pathway involved in osteoblast differentiation JO - Cell Death Differ VL - 22 UR - https://doi.org/10.1038/cdd.2014.238 DO - 10.1038/cdd.2014.238 ID - Kim2015 ER - TY - JOUR AU - Gortazar, A. R. AU - Martin-Millan, M. AU - Bravo, B. AU - Plotkin, L. I. AU - Bellido, T. PY - 2013 DA - 2013// TI - Crosstalk between caveolin-1/extracellular signal-regulated kinase (ERK) and beta-catenin survival pathways in osteocyte mechanotransduction JO - J Biol Chem VL - 288 UR - https://doi.org/10.1074/jbc.M112.437921 DO - 10.1074/jbc.M112.437921 ID - Gortazar2013 ER - TY - JOUR AU - Kitase, Y. AU - Barragan, L. AU - Qing, H. AU - Kondoh, S. AU - Jiang, J. X. AU - Johnson, M. L. AU - Bonewald, L. F. PY - 2010 DA - 2010// TI - Mechanical induction of PGE2 in osteocytes blocks glucocorticoid-induced apoptosis through both the beta-catenin and PKA pathways JO - J Bone Miner Res VL - 25 UR - https://doi.org/10.1002/jbmr.168 DO - 10.1002/jbmr.168 ID - Kitase2010 ER - TY - JOUR AU - Almeida, M. AU - Han, L. AU - Bellido, T. AU - Manolagas, S. C. AU - Kousteni, S. PY - 2005 DA - 2005// TI - Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT JO - J Biol Chem VL - 280 UR - https://doi.org/10.1074/jbc.M502168200 DO - 10.1074/jbc.M502168200 ID - Almeida2005 ER - TY - JOUR AU - Kook, S. H. AU - Lee, D. AU - Cho, E. S. AU - Heo, J. S. AU - Poudel, S. B. AU - Ahn, Y. H. AU - Hwang, J. W. AU - Ji, H. AU - Kim, J. G. AU - Lee, J. C. PY - 2016 DA - 2016// TI - Activation of canonical Wnt/beta-catenin signaling inhibits H2O2-induced decreases in proliferation and differentiation of human periodontal ligament fibroblasts JO - Mol Cell Biochem VL - 411 UR - https://doi.org/10.1007/s11010-015-2570-4 DO - 10.1007/s11010-015-2570-4 ID - Kook2016 ER - TY - JOUR AU - Lancon, A. AU - Frazzi, R. AU - Latruffe, N. PY - 2016 DA - 2016// TI - Anti-oxidant, anti-inflammatory and anti-Angiogenic properties of resveratrol in ocular diseases JO - Molecules VL - 21 UR - https://doi.org/10.3390/molecules21030304 DO - 10.3390/molecules21030304 ID - Lancon2016 ER - TY - JOUR AU - Liu, F. C. AU - Tsai, Y. F. AU - Tsai, H. I. AU - Yu, H. P. PY - 2015 DA - 2015// TI - Anti-inflammatory and organ-protective effects of resveratrol in trauma-hemorrhagic injury JO - Mediat Inflamm VL - 2015 ID - Liu2015 ER - TY - JOUR AU - Venigalla, M. AU - Sonego, S. AU - Gyengesi, E. AU - Sharman, M. J. AU - Munch, G. PY - 2016 DA - 2016// TI - Novel promising therapeutics against chronic neuroinflammation and neurodegeneration in Alzheimer's disease JO - Neurochem Int VL - 95 UR - https://doi.org/10.1016/j.neuint.2015.10.011 DO - 10.1016/j.neuint.2015.10.011 ID - Venigalla2016 ER - TY - JOUR AU - Dai, Z. AU - Li, Y. AU - Quarles, L. D. AU - Song, T. AU - Pan, W. AU - Zhou, H. AU - Xiao, Z. PY - 2007 DA - 2007// TI - Resveratrol enhances proliferation and osteoblastic differentiation in human mesenchymal stem cells via ER-dependent ERK1/2 activation JO - Phytomedicine VL - 14 UR - https://doi.org/10.1016/j.phymed.2007.04.003 DO - 10.1016/j.phymed.2007.04.003 ID - Dai2007 ER - TY - JOUR AU - Zhou, H. AU - Shang, L. AU - Li, X. AU - Zhang, X. AU - Gao, G. AU - Guo, C. AU - Chen, B. AU - Liu, Q. AU - Gong, Y. AU - Shao, C. PY - 2009 DA - 2009// TI - Resveratrol augments the canonical Wnt signaling pathway in promoting osteoblastic differentiation of multipotent mesenchymal cells JO - Exp Cell Res VL - 315 UR - https://doi.org/10.1016/j.yexcr.2009.07.030 DO - 10.1016/j.yexcr.2009.07.030 ID - Zhou2009 ER - TY - JOUR AU - Abed, E. AU - Delalandre, A. AU - Lajeunesse, D. PY - 2017 DA - 2017// TI - Beneficial effect of resveratrol on phenotypic features and activity of osteoarthritic osteoblasts JO - Arthritis Res Ther VL - 19 UR - https://doi.org/10.1186/s13075-017-1365-2 DO - 10.1186/s13075-017-1365-2 ID - Abed2017 ER - TY - JOUR AU - Libert, S. AU - Pointer, K. AU - Bell, E. L. AU - Das, A. AU - Cohen, D. E. AU - Asara, J. M. AU - Kapur, K. AU - Bergmann, S. AU - Preisig, M. AU - Otowa, T. PY - 2011 DA - 2011// TI - SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive JO - Cell VL - 147 UR - https://doi.org/10.1016/j.cell.2011.10.054 DO - 10.1016/j.cell.2011.10.054 ID - Libert2011 ER - TY - JOUR PY - 2015 DA - 2015// TI - Sparse whole-genome sequencing identifies two loci for major depressive disorder JO - Nature VL - 523 UR - https://doi.org/10.1038/nature14659 DO - 10.1038/nature14659 ID - ref44 ER - TY - JOUR AU - Stubbs, B. AU - Hert, M. AU - Sepehry, A. A. AU - Correll, C. U. AU - Mitchell, A. J. AU - Soundy, A. AU - Detraux, J. AU - Vancampfort, D. PY - 2014 DA - 2014// TI - A meta-analysis of prevalence estimates and moderators of low bone mass in people with schizophrenia JO - Acta Psychiatr Scand VL - 130 UR - https://doi.org/10.1111/acps.12313 DO - 10.1111/acps.12313 ID - Stubbs2014 ER - TY - JOUR AU - O'Keane, V. PY - 2008 DA - 2008// TI - Antipsychotic-induced hyperprolactinaemia, hypogonadism and osteoporosis in the treatment of schizophrenia JO - J Psychopharmacol VL - 22 UR - https://doi.org/10.1177/0269881107088439 DO - 10.1177/0269881107088439 ID - O'Keane2008 ER -