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Fig. 3 | BMC Pharmacology and Toxicology

Fig. 3

From: Atypical antipsychotics induce human osteoblasts apoptosis via Wnt/β-catenin signaling

Fig. 3

APs-induced apoptosis related to inhibition of Wnt/β-catenin signaling in OB cells. a, apoptosis-related protein and β-catenin protein expression was measured by western blot after exposured to olanzapine (Ola, 40 μM), risperidone (Ris, 40 μM), amisulpride (Ami, 30 μM) or aripiprazole (Ari, 12 μM) treatment at 24 h in OB cells. b, Nuclear and cytoplasmic protein of β-catenin were analyzed by western blot after exposured to olanzapine (40 μM), risperidone (40 μM), amisulpride (30 μM) or aripiprazole (12 μM) at 24 h in OB cells. c, The different expression of β-catenin protein between nuclear and cytoplasm was determined by Immunoflourescence analysis after exposured to olanzapine (40 μM), risperidone (40 μM), amisulpride (30 μM) or aripiprazole (12 μM) at 24 h in OB cells. The data were calculated with GraphPad Prism. *P < 0.05; **P < 0.01

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