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Table 4 Effect of the CNBP on the stomach homogenate endogenous antioxidant enzymes activities and, MDA and PGE2 levels, and protein concentration (n = 3)

From: Gastroprotective activity of a novel Schiff base derived dibromo substituted compound against ethanol-induced acute gastric lesions in rats

Animal groups

SOD

CAT

MDA

PGE2

Protein concentration

(U/mg protein)

(nmoL/min/mL protein)

(μmoL/g protein)

(ng/mg protein)

(mg/mL tissue)

10% Tween 20 (Normal control)

17.15 ± 0.90***

(p-value < 0.001)

82.51 ± 2.17***

(p-value < 0.001)

62.31 ± 2.90***

(p-value < 0.001)

3.08 ± 0.11***

(p-value < 0.001)

9.00 ± 0.11***

(p-value < 0.001)

Absolute EtOH (Ulcer control)

4.04 ± 0.33

18.70 ± 0.71

146.80 ± 3.53

1.01 ± 0.03

5.12 ± 0.40

Omeprazole (20 mg/kg)

20.07 ± 0.50***

(p-value < 0.001)

100.34 ± 0.56***

(p-value < 0.001)

82.64 ± 3.52***

(p-value < 0.001)

2.95 ± 0.06***

(p-value < 0.001)

7.71 ± 0.88**

(p-value = 0.003)

CNBP (LD)

12.22 ± 0.58***

(p-value < 0.001)

42.45 ± 2.48*

(p-value = 0.04)

112.48 ± 7.47*

(p-value = 0.04)

2.59 ± 0.24***

(p-value < 0.001)

6.03 ± 0.17

(p-value = 0.06)

CNBP (HD)

19.12 ± 1.14***

(p-value < 0.001)

68.30 ± 2.88***

(p-value < 0.001)

101.01 ± 7.67**

(p-value = 0.002)

2.88 ± 0.15* **

(p-value < 0.001)

6.72 ± 0.15*

(p-value = 0.04)

  1. All values (in triplicate) are expressed as the mean ± SEM. significant at * p < 0.05, ** p < 0.01, and *** p < 0.001 compared to ulcerated group