Skip to main content

Table 4 Effect of the CNBP on the stomach homogenate endogenous antioxidant enzymes activities and, MDA and PGE2 levels, and protein concentration (n = 3)

From: Gastroprotective activity of a novel Schiff base derived dibromo substituted compound against ethanol-induced acute gastric lesions in rats

Animal groups SOD CAT MDA PGE2 Protein concentration
(U/mg protein) (nmoL/min/mL protein) (μmoL/g protein) (ng/mg protein) (mg/mL tissue)
10% Tween 20 (Normal control) 17.15 ± 0.90***
(p-value < 0.001)
82.51 ± 2.17***
(p-value < 0.001)
62.31 ± 2.90***
(p-value < 0.001)
3.08 ± 0.11***
(p-value < 0.001)
9.00 ± 0.11***
(p-value < 0.001)
Absolute EtOH (Ulcer control) 4.04 ± 0.33 18.70 ± 0.71 146.80 ± 3.53 1.01 ± 0.03 5.12 ± 0.40
Omeprazole (20 mg/kg) 20.07 ± 0.50***
(p-value < 0.001)
100.34 ± 0.56***
(p-value < 0.001)
82.64 ± 3.52***
(p-value < 0.001)
2.95 ± 0.06***
(p-value < 0.001)
7.71 ± 0.88**
(p-value = 0.003)
CNBP (LD) 12.22 ± 0.58***
(p-value < 0.001)
42.45 ± 2.48*
(p-value = 0.04)
112.48 ± 7.47*
(p-value = 0.04)
2.59 ± 0.24***
(p-value < 0.001)
6.03 ± 0.17
(p-value = 0.06)
CNBP (HD) 19.12 ± 1.14***
(p-value < 0.001)
68.30 ± 2.88***
(p-value < 0.001)
101.01 ± 7.67**
(p-value = 0.002)
2.88 ± 0.15* **
(p-value < 0.001)
6.72 ± 0.15*
(p-value = 0.04)
  1. All values (in triplicate) are expressed as the mean ± SEM. significant at * p < 0.05, ** p < 0.01, and *** p < 0.001 compared to ulcerated group