Skip to main content
Fig. 5 | BMC Pharmacology and Toxicology

Fig. 5

From: Histone deacetylase inhibition by Entinostat for the prevention of electrical and structural remodeling in heart failure

Fig. 5

Effects of pacing and Entinostat treatment on the development of cardiac fibrosis in vivo. a Representative images of Picosirius Red staining of non-stimulated rabbit hearts and ventricular stimulated hearts treated with 0.5 ml/d DMSO (control) or 0.01 g/d Entinostat for 10 days. b The fibrotic areas were quantified by ImageJ software (dark blue: failing hearts treated with DMSO (n = 6); light blue: sham-operated hearts treated with DMSO (n = 7); red: failing hearts treated with Entinostat (n = 6) and orange: sham-operated hearts treated with Entinostat (n = 9) (control hearts treated with DMSO vs. failing hearts treated with DMSO p = 0.002, failing hearts treated with DMSO vs. failing hearts treated with Entinostat p = 0.003 (*))

Back to article page