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Table 1 Effects of Sacubitril, Sacubitril-Aliskiren and Sacubitril-Ramipril on cardiac and renal biomarkers: troponin I, NT-proBNP, CK-MB, MMP9 and renin

From: Effects of neprilysin-renin inhibition in comparison with neprilysin-angiotensin inhibition on the neurohumoral changes in rats with heart failure

Parameter Control Heart failure Sacubitril Ramipril & sacubitril Aliskiren & sacubitril
troponin I ng/ml 0.62 ± 0.12 3.09 ± 0.147** 2.32 ± .0.28 2.1 ± 0.16* 1.78 ± 0.201*
NT-proBNP pg/ml 356 ± 27.61 980 ± 116.71** 658 ± 58.68* 471.66 ± 43.58* 462 ± 35.52*
CK-MB ng/ml 13.78 ± 1.67 31.55 ± 1.69** 28.71 ± 3.12 17 ± 3.7* 22.18 ± 1.63
MMP9 ng/ml 9.91 ± 0.43 15.85 ± 0.57** 12.45 ± 1.1* 11.99 ± 0.93* 11.3 ± 0.73*
renin pg/ml 408 ± 11.456 736 ± 45.8 693 ± 42.35 830.33 ± 23.35 836 ± 0.73*
  1. Values are expressed as mean ± SEM
  2. *P < 0.05 when compared with group II
  3. **P < 0.05 when compared with group I
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