Table 1 Effects of Sacubitril, Sacubitril-Aliskiren and Sacubitril-Ramipril on cardiac and renal biomarkers: troponin I, NT-proBNP, CK-MB, MMP9 and renin

troponin I ng/ml

0.62 ± 0.12

3.09 ± 0.147^**

2.32 ± .0.28

2.1 ± 0.16^*

1.78 ± 0.201^*

NT-proBNP pg/ml

356 ± 27.61

980 ± 116.71^**

658 ± 58.68^*

471.66 ± 43.58^*

462 ± 35.52^*

CK-MB ng/ml

13.78 ± 1.67

31.55 ± 1.69^**

28.71 ± 3.12

17 ± 3.7^*

22.18 ± 1.63

MMP9 ng/ml

9.91 ± 0.43

15.85 ± 0.57^**

12.45 ± 1.1^*

11.99 ± 0.93^*

11.3 ± 0.73^*

renin pg/ml

408 ± 11.456

736 ± 45.8

693 ± 42.35

830.33 ± 23.35

836 ± 0.73^*