Table 2 Effects of Sacubitril, Sacubitril-Aliskiren and Sacubitril-Ramipril on renal function: GFR, creatinine, urine flow and total solute excretion

GFR ml/h/kg

140.5 ± 14.7

7.031 ± 1.6

248.76 ± 44.91^*

213.30 ± 29.81^*

270.24 ± 73.31^*

BUN mg/dl

32.5 ± 1.05

52.1 ± 1.57^**

47.2 ± 2.13

49.3 ± 3.35

35.93 ± 7.8

Creatinine mg/dl

0.37 ± 0.02

0.92 ± 0.04^**

0.498 ± 0.02^*

0.67 ± 0.02^*

0.66 ± 0.04^*

Urine flow ml/h/kg

0.525 ± 0.09

0.2761 ± 0.06

1.0607 ± 0.23^*

0.9593 ± 0.15^*

1.0776 ± 0.23^*

Total solute excretion meq/minute

0.594 ± 0.06

0.11 ± 0.03

0.912 ± 0.235^*

0.765 ± 0.11

1.01 ± 0.29^*