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Table 2 Effects of Sacubitril, Sacubitril-Aliskiren and Sacubitril-Ramipril on renal function: GFR, creatinine, urine flow and total solute excretion

From: Effects of neprilysin-renin inhibition in comparison with neprilysin-angiotensin inhibition on the neurohumoral changes in rats with heart failure

Parameter Control Heart failure Sacubitril Ramipril & sacubitril Aliskiren & sacubitril
GFR ml/h/kg 140.5 ± 14.7 7.031 ± 1.6 248.76 ± 44.91* 213.30 ± 29.81* 270.24 ± 73.31*
BUN mg/dl 32.5 ± 1.05 52.1 ± 1.57** 47.2 ± 2.13 49.3 ± 3.35 35.93 ± 7.8
Creatinine mg/dl 0.37 ± 0.02 0.92 ± 0.04** 0.498 ± 0.02* 0.67 ± 0.02* 0.66 ± 0.04*
Urine flow ml/h/kg 0.525 ± 0.09 0.2761 ± 0.06 1.0607 ± 0.23* 0.9593 ± 0.15* 1.0776 ± 0.23*
Total solute excretion meq/minute 0.594 ± 0.06 0.11 ± 0.03 0.912 ± 0.235* 0.765 ± 0.11 1.01 ± 0.29*
  1. Values are expressed as mean ± SEM
  2. *P < 0.05 when compared with group II
  3. **P < 0.05 when compared with group I
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