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Table 3 Effects of Sacubitril, Sacubitril-Aliskiren and Sacubitril-Ramipril on arterial blood pressure and heart rate: systolic blood pressure, diastolic blood pressure, mean blood pressure, and heart rate

From: Effects of neprilysin-renin inhibition in comparison with neprilysin-angiotensin inhibition on the neurohumoral changes in rats with heart failure

Parameter

Control

Heart failure

Sacubitril

Ramipril & sacubitril

Aliskiren & sacubitril

Systolic blood pressure mm Hg

116.16 ± 1.6

104.16 ± 3.45**

91 ± 1.34*

95 ± 3.14

84.66 ± 2.96*

Diastolic blood pressure mm Hg

85.5 ± 0.56

72.5 ± 1.8**

66.3 ± 0.71

75.3 ± 3.6

65.3 ± 3.1

Mean blood pressure mm Hg

97.3 ± 0.76

83.5 ± 2.6**

74.3 ± 0.8*

80.16 ± 2.3

71.5 ± 2.94*

Heart rate beat/minutes

355 ± 18.2

505.8 ± 15.15**

427 ± 8.56*

368.8 ± 12.7*

400.16 ± 25.8*

  1. Values are expressed as mean ± SEM
  2. *P < 0.05 when compared with group II
  3. **P < 0.05 when compared with group I