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Table 3 Effects of Sacubitril, Sacubitril-Aliskiren and Sacubitril-Ramipril on arterial blood pressure and heart rate: systolic blood pressure, diastolic blood pressure, mean blood pressure, and heart rate

From: Effects of neprilysin-renin inhibition in comparison with neprilysin-angiotensin inhibition on the neurohumoral changes in rats with heart failure

Parameter Control Heart failure Sacubitril Ramipril & sacubitril Aliskiren & sacubitril
Systolic blood pressure mm Hg 116.16 ± 1.6 104.16 ± 3.45** 91 ± 1.34* 95 ± 3.14 84.66 ± 2.96*
Diastolic blood pressure mm Hg 85.5 ± 0.56 72.5 ± 1.8** 66.3 ± 0.71 75.3 ± 3.6 65.3 ± 3.1
Mean blood pressure mm Hg 97.3 ± 0.76 83.5 ± 2.6** 74.3 ± 0.8* 80.16 ± 2.3 71.5 ± 2.94*
Heart rate beat/minutes 355 ± 18.2 505.8 ± 15.15** 427 ± 8.56* 368.8 ± 12.7* 400.16 ± 25.8*
  1. Values are expressed as mean ± SEM
  2. *P < 0.05 when compared with group II
  3. **P < 0.05 when compared with group I
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