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Table 1 The length of time at which adverse effect significantly manifested on Balb c mice treated with test chemicals orally

From: Study of the principles in the first phase of experimental pharmacology: the basic step with assumption hypothesis

Test chemical

Doses tested

â„– of Mice

Weight in gm

Time at which test substance administered

Time at which signs of adverse effect clearly manifested

Duration

1.1.Dichlorvos

10 mg/kg

1

15.13

10:22

11:22

1 h

50 mg/kg

1

17.63

10:23

10:53

30 min

90 mg/kg

1

16.42

10:24

10:39

15 min

1.1.Chlorpyrifos

10 mg/kg

1

30.41

10:28

13:00

2:30 h

50 mg/kg

1

27.12

10:29

12:00

1:30 h

90 mg/kg

1

26.84

10:30

11:00

30 min

1.1.Cypermethrin

10 mg/kg

1

28.42

10:32

10:55

23 min

50 mg/kg

1

30.98

10:33

10:45

12 min

90 mg/kg

1

28.24

10:36

10:45

9 min