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Table 4 Changes in concentration of serum immunoglobulins at four hour after treatment of Balb-c mice with different doses of test chemicals

From: Study of the principles in the first phase of experimental pharmacology: the basic step with assumption hypothesis

Test chemical Tested doses Quantitative immunoassay before treatment as reference test Quantitative immunoassay at four hour after treatment for comparison ΔIg serum conc.
IgG IgM IgG IgM Δ Ig
1.1.Dichlorvos 10 mg/kg < 1100 mg/L 70 mg/L < 1100 mg/L 90 mg/L + 20 mg/L
50 mg/kg < 1100 mg/L 70 mg/L < 1100 mg/L 80 mg/L + 10 mg/L
90 mg/kg X X X X X
1.1.Chlorpyrifos 10 mg/kg < 1100 mg/L 90 mg/L < 1100 mg/L 120 mg/L + 30 mg/L
50 mg/kg < 1100 mg/L 50 mg/L < 1100 mg/L 70 mg/L + 20 mg/L
90 mg/kg < 1100 mg/L 90 mg/L < 1100 mg/L 80 mg/L − 10 mg/L
1.1.Cypermethrin 10 mg/kg < 1100 mg/L 70 mg/L < 1100 mg/L 90 mg/L + 20 mg/L
50 mg/kg < 1100 mg/L 80 mg/L < 1100 mg/L 70 mg/L − 10 mg/L
90 mg/kg < 1100 mg/L 80 mg/L < 1100 mg/L 50 mg/L − 30 mg/L
  1. Xrepresents treated mouse which died much earlier than the time for blood specimen collection
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