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Table 5 The effect of different doses of Dichlorvos on Balb c mice which were administered orally using interagasteral tube

From: Study of the principles in the first phase of experimental pharmacology: the basic step with assumption hypothesis

Dose in mg/kg 10 50 90
Number of mice treated 1 1 1
Adverse effects within 24 hrs ❖ Hypo-activity
❖ Weak
❖ Slow respiration
❖ Hypo-activity
❖ Weak
❖ Slow respiration
❖ Hypo-activity
❖ Weak
❖ Slow respiration
❖ Died after 1:36 hours
Adverse effects within 48 hrs ❖ Increased activity ❖ Slightly increased activity  
Adverse effects within 72 hrs ❖ Recovered ❖ Slightly recovered  
Adverse effects within 96 hrs ❖ Completely recovered ❖ Recovered  
Adverse effects within 120 hrs ❖ Weight loss ❖ Weight loss  
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