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Table 5 The effect of different doses of Dichlorvos on Balb c mice which were administered orally using interagasteral tube

From: Study of the principles in the first phase of experimental pharmacology: the basic step with assumption hypothesis

Dose in mg/kg

10

50

90

Number of mice treated

1

1

1

Adverse effects within 24 hrs

❖ Hypo-activity

❖ Weak

❖ Slow respiration

❖ Hypo-activity

❖ Weak

❖ Slow respiration

❖ Hypo-activity

❖ Weak

❖ Slow respiration

❖ Died after 1:36 hours

Adverse effects within 48 hrs

❖ Increased activity

❖ Slightly increased activity

 

Adverse effects within 72 hrs

❖ Recovered

❖ Slightly recovered

 

Adverse effects within 96 hrs

❖ Completely recovered

❖ Recovered

 

Adverse effects within 120 hrs

❖ Weight loss

❖ Weight loss