Skip to main content

Table 2 MIC values of three Epinecidin-1 derivatives in exposure to various pathogens

From: Epinecidin-1, a highly potent marine antimicrobial peptide with anticancer and immunomodulatory activities

   MIC (μg/ml)
   Epinecidin-1 23–47
[7]
Epinecidin-1 22–51
[10]
Epinecidin-1 22–42
[10, 18, 20, 28, 29, 31]
Gram-positive bacteria Listeria monocytogenes (BCRC14930) 25 50
Bacillus subtilis > 200
Micrococcus luteus (BCRC11034) 3.125 25
Staphylococcus aureus (BCRC10780) 6.25 9.7–12.5
Streptococcus pyogenes (BCRC10797) 25 25
Streptococcus agalactiae (819) 12.5 50
Staphylococcus epidermidis (BCRC10783) 12.5 > 100
Staphylococcus sp. (BCRC10451) 6.25 50
Staphylococcus xylosus (BCRC12930) > 100 50
Streptococcus pneumoniae (BCRC10794) 12.5 25
Staphylococcus aureus subsp. (BCRC10782) 6.25 6.25
Propionibacterium acnes 200
Gram-negative bacteria Helicobacter pylori 8–12
Enterobacter aerogenes (BCRC10370) 25 50
Enterobacter cloacae subsp. (BCRC10401) 100 100
Vibrio alginolyticus 12.5 100
Klebsiella oxytoca (BCRC13985) 25 50
Salinivibrio costicola subsp. (BCRC12910) 3.125 12.5
Vibrio parahaemolyticus < 0.4
Vibrio vulnificus (YJ016) 3.125 12.5
Vibrio harveyi (BCRC13812) 3.125 12.5
Vibrio harveyi (BCRC12907) 6.25 12.5
Vibrio vulnificus 12.5 6.25 12.5
Vibrio alginolyticus (BCRC12829) 0.77 6.25 12.5
Pasteurella multocida 0.77
Morganella morganii 0.77
Aeromonas sobrio 3.11
Aeromonas hydrophila 3.11
Escherichia coli 6.24
Pseudomonas aeruginosa > 100 60
Pseudomonas fluorescens 200
Yersinia enterocolitica subsp. (BCRC13999) 100 100
Flavobacterium meningosepticum < 0.4
Riemerella anatipestifer (11 different strains) 6.25–50 (Average 27.8)
Other Trichomonas vaginalis (ATCC 50143)    25–62.5
Trichomonas vaginalis 12.5
Candida albicans 25 25
Pichia pastoris 495
Microsporosis canis 50
Trichophytonsis mentagrophytes 100
Cylindrocarpon sp. 100