- Lack of standardized terminology to describe an interaction or its outcome | |
- Heterogeneous criteria for severity classification | |
- Inconsistent evaluation of evidence of the DDI | |
- Variable reliance on sources such as non-English journal articles, postmarketing surveillance and product labeling | |
- Inconsistent extrapolation of interactions to other drugs in the same class | |
- Some knowledge bases intend to be highly inclusive, with an emphasis on breadth of coverage rather than clinical relevance due to medicolegal concerns | |
- Various purposes intended for the database | |
- Differences in the frequency of updates and latency of adopting new evidences |