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Table 1 Reasons for discrepancies among drug interaction compendia [4, 8]

From: Countrywide prevalence of critical drug interactions in Hungarian outpatients: a retrospective analysis of pharmacy dispensing data

- Lack of standardized terminology to describe an interaction or its outcome
- Heterogeneous criteria for severity classification
- Inconsistent evaluation of evidence of the DDI
- Variable reliance on sources such as non-English journal articles, postmarketing surveillance and product labeling
- Inconsistent extrapolation of interactions to other drugs in the same class
- Some knowledge bases intend to be highly inclusive, with an emphasis on breadth of coverage rather than clinical relevance due to medicolegal concerns
- Various purposes intended for the database
- Differences in the frequency of updates and latency of adopting new evidences