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Lexicomp Drug Interactions
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5 risk ratings:
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X – Avoid Combination,
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D – Consider Therapy Modification,
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C – Monitor Therapy,
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B – No Action Needed,
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A – No Known Interaction.
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3 severity ratings: Major, Moderate, Minor.
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4 reliability ratings: Excellent, Good, Fair, Poor.
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Medscape Drug Interaction Checker
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4 categories:
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Contraindicated,
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Serious – Use Alternative,
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Monitor Closely,
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Minor.
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Drugs.com
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4 categories:
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Major – Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
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Moderate – Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
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Minor – Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
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Unknown – No information available.
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Janusmed Interactions
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4 clinical relevance ratings:
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D – Clinically relevant interaction. The combination is best avoided.
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C – Clinically relevant interaction that can be handled e.g. by dose adjustments.
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B – Clinical outcome of the interaction is uncertain and/or may vary.
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A – Minor interaction of no clinical relevance.
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4-point scale for the level of documentation
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ORCA
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5 classes:
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Class 1 – Contraindicated (Risk of combination outweighs benefit),
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Class 2 – Provisionally contraindicated (Use only under special circumstances),
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Class 3 – Conditional (Assess risk and take actions if needed),
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Class 4 – Minimal Risk (Risk of adverse outcome appears small),
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Class 5 – No interaction (Evidence suggest that the drugs do not interact).
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