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Table 2 Classification of DDIs in the selected sources

From: Countrywide prevalence of critical drug interactions in Hungarian outpatients: a retrospective analysis of pharmacy dispensing data

Name Categories
Lexicomp Drug Interactions 5 risk ratings:
X – Avoid Combination,
D – Consider Therapy Modification,
C – Monitor Therapy,
B – No Action Needed,
A – No Known Interaction.
3 severity ratings: Major, Moderate, Minor.
4 reliability ratings: Excellent, Good, Fair, Poor.
Medscape Drug Interaction Checker 4 categories:
Contraindicated,
Serious – Use Alternative,
Monitor Closely,
Minor.
Drugs.com 4 categories:
Major – Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate – Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor – Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown – No information available.
Janusmed Interactions 4 clinical relevance ratings:
D – Clinically relevant interaction. The combination is best avoided.
C – Clinically relevant interaction that can be handled e.g. by dose adjustments.
B – Clinical outcome of the interaction is uncertain and/or may vary.
A – Minor interaction of no clinical relevance.
4-point scale for the level of documentation
ORCA 5 classes:
Class 1 – Contraindicated (Risk of combination outweighs benefit),
Class 2 – Provisionally contraindicated (Use only under special circumstances),
Class 3 – Conditional (Assess risk and take actions if needed),
Class 4 – Minimal Risk (Risk of adverse outcome appears small),
Class 5 – No interaction (Evidence suggest that the drugs do not interact).