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Table 3 Significant Risk factors determining odds of being acute vs. chronic Methotrexate toxicity (n = 27)

From: Acute versus chronic methotrexate poisoning; a cross-sectional study

Characteristics Acute (n = 13) Chronic (n = 14) p value OR (95%CI)
RA Background disease n(%) 3 (23.1) 10 (76.9) 0.021 8.3 (1.4, 47.2)
MTX oral formulation 13 (61.9) 8 (38.1) 0.016 1.8 (1.1, 2.8)
MTX injection formulation 0 5 (100) 0.041 1.6 (1.1, 2.3)
Suicide Attempt n(%) 10 (100) 0 > 0.001 0.23 (0.07, 0.62)
Error in time of prescription drug n(%) 0 5 (100) 0.041 1.6 (1.1, 2.3)
Skin lesions n(%) 0 6 (100) 0.016 1.7 [1.1, 2.7)
Oral ulcerations n(%) 0 13 (100) > 0.001 14 (2.1, 92.5)
Leukopenia n(%) 1 (7.7) 12 (92.3) > 0.001 72 (5.7, 904.1)
Thrombocytopenia n(%) 1 (7.7) 14 (100) > 0.001 15 (2.3, 99.6)
Anemia n(%) 9 (39.1) 14 (60.9) 0.041 0.69 (0.48, 0.99)