The effects of thiamine pyrophosphate on ethanol induced optic nerve damage

Table 1 The results of biochemical evaluations of serum samples among groups

	HC (n:6)	EtOH (n:6)	TEt-20 (n:6)	TPG (n:6)	p
sIL-1β	3.60 ± 0.35^b,c	8.15 ± 0.35^a,c,d	4.23 ± 0.48^a,b,d	3.83 ± 0.36^b,c	0.001
sTNF-α	2.85 ± .018^b,c	6.53 ± 0.41^a,c,d	3.51 ± 0.31^a,b,d	3.08 ± 0.194^b,c	0.001
sMDA	1.75 ± 0.18^b,c	4.78 ± 0.19^a,c,d	2.21 ± 0.27^a,b,d	1.58 ± 0.24^b,c	0.001
sGSH	5.91 ± 0.26^b,c	1.61 ± 0.33^a,c,d	5.16 ± 0.16^a,b,d	6.31 ± 0.33^b,c	0.001

HC Healthy controls, EtOH ethanol group, TEt-20 ethanol + thiamine pyrophosphate group, TPG thiamine pyrophosphate group. MDA Malondialdehyde, GSH total glutathione, IL-1β interleukin 1 beta, TNF-α tumor necrosis factor alpha, s serum. ^a: statistically significantly different compared with HC; ^b: statistically significantly different compared with EtOH; ^c: statistically significantly different compared with TEt-20; ^d: statistically significantly different compared with TPG. (Statistical significance was set at p < 0.05)

ISSN: 2050-6511