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Table 3 Prognostic effects of drugs in CAD patients with and without low GFR

From: Relationship between drug application and mortality rate in Chinese older coronary artery disease/chronic heart failure patients with and without low glomerular filtration rate

Drugs

Without low GFR

With low GFR

Survival time (days)

P value*

P value**

Survival time (days)

P value*

P value**

No use

Use

No use

Use

Aspirin

883 (828–937)

1086 (1019–1152)

0.023

0.173

900 (785–1015)

813 (718–908)

0.349

0.445

Clopidogrel

946 (877–1015)

1088 (1024–1153)

0.008

0.028

942 (835–1050)

739 (646–832)

0.718

0.871

Beta-blockers

964 (915–1014)

1024 (961–1088)

0.155

0.436

1118 (1017–1220)

724 (635–813)

0.013

0.388

CCBs

899 (840–958)

1062 (996–1129)

0.209

0.499

711 (602–821)

910 (808–1013)

0.432

0.223

Nitrates

903 (841–965)

1038 (981–1095)

0.246

0.692

908 (760–1056)

867 (769–966)

0.225

0.460

ACEI/ARBs

1026 (947–1105)

1077 (1007–1148)

0.033

0.426

816 (698–934)

835 (745–926)

0.046

0.671

Statins

903 (821–986)

1136 (1077–1194)

< 0.001

< 0.001

796 (656–937)

811 (729–892)

0.002

0.225

  1. *Relationship of drugs with survival time was bivariately evaluated with Kaplan-Meier analysis; **relationship of drugs with mortality rate was multivariately adjusted by age, gender, body mass index, CAD, CHF, atrial fibrillation, hypertension, heart rate, systolic blood pressure, diastolic blood pressure, hemoglobin, albumin, glomerular filtration rate, fasting plasma glucose, triglyceride, low density lipoprotein cholesterol and high density lipoprotein cholesterol using Cox Regression
  2. Abbreviations: ACEI/ARBs Renin-angiotensin-aldosterone system inhibitors/angiotensin receptor blockers, CAD Coronary artery disease, CHF Chronic heart failure, CCBs Calcium channel blockers, GFR Glomerular filtration rate