Skip to main content

Table 2 Effect of BPA on subsequent embryo development after IVF

From: Influence of N-acetyl-L-cysteine against bisphenol a on the maturation of mouse oocytes and embryo development: in vitro study

Bisphenol A Concentration(μg/mL) ooctyes inseminated oocytes fertilized (%) 4-cell rate (%) Blastocysts rate (%)
(Control)0 105 86.7 ± 1.0a 85.7 ± 1.4a 64.8 ± 1.8a
20 109 81.1 ± 1.4a 84.4 ± 1.4a 55.5 ± 1.9b
50 107 64.6 ± 2.1b 84.7 ± 2.0a 44.3 ± 3.0c
100 110 38.4 ± 3.0c 83.4 ± 1.7a 24.1 ± 3.4d
  1. After 14 h of maturation, the embryo development of oocytes following IVF was tested. BPA at 50 and 100 μg/mL significantly decreased the rates of fertilization and blastocyst formation. Each treatment was repeated 3 times, and each replicate contained 30–40 oocytes. The data were analysed with one-way ANOVA, followed by Dunnett’s post-hoc test. a-dValues with different superscripts in the same column differ significantly (P < 0.05)