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Table 3 Effect of 100 μM NAC on the 50 μg/mL BPA-induced defects in fertilization ability and embryo development

From: Influence of N-acetyl-L-cysteine against bisphenol a on the maturation of mouse oocytes and embryo development: in vitro study

Groups

oocytes fertilized (%)

Blastocysts rate (%)

Control

87.0 ± 1.1a

62.1 ± 3.1a

NAC (100 μM)

86.0 ± 1.4a

63.1 ± 2.1a

BPA(50 μg/mL)

66.0 ± 2.2b

45.9 ± 3.0b

NAC (100 μM) + BPA(50 μg/mL)

81.5 ± 2.3a

57.0 ± 4.1a

  1. N-Acetyl-L-cysteine (NAC, 100 μM); Bisphenol A (BPA, 50 μg/mL); NAC + BPA, combined treatment with NAC (100 μM) and BPA (50 μg/mL). After 14 h of maturation in the presence of 100 μM NAC and 50 μg/mL BPA, the oocytes were fertilized in vitro and then cultured to blastocysts. In the NAC + BPA group, the rates of fertilization and blastocyst formation were higher than those in the BPA group. Each treatment was repeated 3 times, and each replicate contained 30–40 oocytes. One-way ANOVA with Dunnett’s post hoc test was used to analyse the data. a, bValues without a common letter above the bars in the same column are significantly different (P < 0.05)
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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