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Fig. 3 | BMC Pharmacology and Toxicology

Fig. 3

From: Identification of undecylenic acid as EAG channel inhibitor using surface plasmon resonance-based screen of KCNH channels

Fig. 3

Undecylenic acid is a novel small molecule binder of the PAS domain of mEAG channels. a Chemical structure of undecylenic acid identified as the mEAG PAS domain specific binder with the SPR-based screening method. SPR sensorgrams recorded for the immobilized PAS domains of mEAG (b), hERG (c) and hELK (d), and C-linker/CNB(CNBH) domains of hHCN4 (e), mEAG (f), hERG (g) and hELK (h) channels recorded with the indicated concentration of undecylenic acid

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