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Table 6 Prescribed drugs’ doses of the top-10 interactions

From: Potential drug-drug interactions among pneumonia patients: do these matter in clinical perspectives?

Interacting pairDose categoriesaPrescribed dose regimenNumber of patients
Aspirin + FurosemideLow + Low75 mg OD + 40 mg OD17
Low + High75 mg OD + 60 mg OD10
Low + Low75 mg OD + 20 mg OD5
Low + High75 mg OD + 100 mg OD3
Low + High75 mg OD + 40 mg BD2
Low + High75 mg OD + 60 mg BD2
Low + High75 mg OD + 80 mg OD1
Furosemide + HydrocortisoneLow + High40 mg OD + 100 mg QID5
High + High80 mg OD + 100 mg QID4
Low + Low40 mg OD + 250 mg OD3
High + Low60 mg OD + 50 mg QID3
High + High60 mg OD + 100 mg QID3
Low + High20 mg OD + 100 mg QID3
Low + High20 mg OD + 500 mg OD2
Low + Low40 mg OD + 50 mg QID2
High + Low60 mg OD + 250 mg OD2
High + Low40 mg BD + 50 mg BD1
Low + High40 mg OD + 250 mg TDS1
High + High60 mg OD + 500 mg TDS1
High + Low60 mg BD + 100 mg TDS1
Low + Low40 mg OD + 100 mg BD1
High + Low60 mg OD + 100 mg BD1
High + High80 mg BD + 100 mg QID1
High + Low60 mg BD + 250 mg OD1
High + Low80 mg OD + 250 mg OD1
High + High100 mg OD + 100 mg QID1
High + High80 mg OD + 500 mg QID1
High + Low60 mg BD + 50 mg TDS1
Aspirin + ClopidogrelLow + Low75 mg OD + 75 mg OD35
High + Low150 mg OD + 75 mg OD1
High + Low300 mg OD + 75 mg OD1
Aspirin + InsulinLow + High75 mg OD + 20–40 units/day21
Low + High75 mg OD + > 40 units/day6
Low + Low75 mg OD + < 20 units/day5
High + Low150 mg OD + 20 units/day1
Isoniazid + RifampinLow + Low75 mg OD + 150 mg OD27
High + High150 mg OD + 300 mg OD6
Calcium containing products + CeftriaxoneLow + Low200 mg/L OD + 2 g OD ATD7
Low + High200 mg/L BD + 2 g BD ATD5
Low + Low200 mg/L BD + 2 g OD ATD4
High + Low1 g OD + 2 g OD ATD4
Low + Low200 mg/L OD + 1 g BD ATD3
Low + Low200 mg/L TDS + 2 g OD ATD2
High + High1 g OD + 2 g BD ATD1
Low + Low200 mg/L BD + 1 g BD ATD1
Low + Low200 mg/L OD + 1 g OD ATD1
Low + Low200 mg/L BD + 1 g OD ATD1
Low + High200 mg/L BD + 3 g BD ATD1
Low + High200 mg/L OD + 4 g OD ATD1
High + High1250 mg BD + 2 g BD ATD1
High + Low1250 mg OD + 2 g OD ATD1
Pyrazinamide + RifampinLow + Low400 mg OD + 150 mg OD28
High + High500 mg OD + 300 mg OD4
Aspirin + RamiprilLow + Low75 mg OD + 2.5 mg OD20
Low + High75 mg OD + 5 mg OD4
Low + High75 mg OD + 10 mg OD3
Low + Low75 mg OD + 1.25 mg OD1
Albuterol + FurosemideHigh + Low5 mg/ml TDS + 40 mg OD13
High + High5 mg/ml TDS + 60 mg OD8
High + Low5 mg/ml TDS + 20 mg OD4
High + High5 mg/ml TDS + 40 mg BD1
Low + Low50mcg/actuation TDS + 40 mg OD1
Low + High2 mg OD + 80 mg BD1
Aspirin + BisoprololLow + Low75 mg OD + 2.5 mg OD14
Low + High75 mg OD + 5 mg OD7
High + High300 mg OD + 5 mg OD1
High + Low150 mg OD + 2.5 mg OD1
  1. OD Once a day, BD Twice a day, QID Four times a day, TDS Three times a day, ATD Alternate day
  2. aThe following cut off points were used for defining higher daily doses, furosemide: ≥60 mg; hydrocortisone: ≥500 mg; aspirin: ≥150 mg; insulin: > 20 units; isoniazid: ≥150 mg; rifampin: ≥300 mg; calcium containing products: ≥1 g; ceftriaxone: ≥4 g; pyrazinamide: ≥500 mg; ramipril: ≥5 mg; albuterol: ≥15 mg/3 ml; bisoprolol: ≥5 mg