Fig. 2

Effect of high-dose (HD, 10 mg/kg × 3) on initiating a syndrome. Occurrence of a syndrome was instrumentally detected with changes in EEG activity under the normal environmental conditions. A Representative samples of baseline (a) and the EEG responses to a first (b), second (c) and third injection (d). B X-axis represents time in hours, starting at 0 when given the first drug administration while y-axis represents % change in power spectral density (PSD) from baseline (N = 6 rats/group). Significant difference from the control group was found in the first injection; F_(1,10) = 5.621, P = 0.0392), but not the second (F_(1,10) = 0.921, P = 0.3598) or third injection (F_(1,10) = 0.552, P = 0.4746). *P < 0.05 vs. the SAL control