Fig. 4From: Differential role of dose and environment in initiating and intensifying neurotoxicity caused by MDMA in ratsEffect of environment on the syndrome intensification. The syndrome intensity was estimated with changes in Tcor under the modified environmental conditions. X-axis represents time in hours, starting at 0 as given the first drug administration of HD (left panel) or LD MDMA (right panel) while y-axis represents changes in Tcor from baseline Arrows indicate the time of binge injections. The red horizontal bars indicate the time period (30 min) of treadmill exercise.10 mg/kg × 3, N = 6 rats/group; 2 mg/kg × 3, N = 6 rats/group. MDMA no longer caused a reduction in Tcor. Instead, there were increases in Tcor (hyperthermia) *P < 0.05 vs. the SAL group of the same time point). *P < 0.05, **P < 0.01 and ***P < 0.001 vs. the SAL group of the same time point)Back to article page