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Fig. 4 | BMC Pharmacology and Toxicology

Fig. 4

From: Differential role of dose and environment in initiating and intensifying neurotoxicity caused by MDMA in rats

Fig. 4

Effect of environment on the syndrome intensification. The syndrome intensity was estimated with changes in Tcor under the modified environmental conditions. X-axis represents time in hours, starting at 0 as given the first drug administration of HD (left panel) or LD MDMA (right panel) while y-axis represents changes in Tcor from baseline Arrows indicate the time of binge injections. The red horizontal bars indicate the time period (30 min) of treadmill exercise.10 mg/kg × 3, N = 6 rats/group; 2 mg/kg × 3, N = 6 rats/group. MDMA no longer caused a reduction in Tcor. Instead, there were increases in Tcor (hyperthermia) *P < 0.05 vs. the SAL group of the same time point). *P < 0.05, **P < 0.01 and ***P < 0.001 vs. the SAL group of the same time point)

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