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Fig. 7 | BMC Pharmacology and Toxicology

Fig. 7

From: Differential role of dose and environment in initiating and intensifying neurotoxicity caused by MDMA in rats

Fig. 7

Effects of MDMA doses and environments, respectively, on initiating and intensifying serotonergic injury. SERT density was used to estimate those effects. a Schematic diagram of the medial FCx and corresponding coronal sections used to assess the SERT-containing fiber density (anterior-posterior location + 3.70 relative to bregma). b Changes in SERT-containing fibers. Bar: 100 μm. c The means of optical densities (arbitrary unit). **P < 0.01 vs. CTL, examined with ANOVA followed by post-hoc test. CTL-S, saline as control; HD-H , high-dose-induced hypothermia; HD-H+, high-dose-induced hyperthermia; LD-H+, low-dose-induced hyperthermia

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