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Fig. 8 | BMC Pharmacology and Toxicology

Fig. 8

From: Differential role of dose and environment in initiating and intensifying neurotoxicity caused by MDMA in rats

Fig. 8

Effects of MDMA doses and environments, respectively, on initiating and intensifying serotonergic injury. Serotonergic axonal retrograde transportation was used to estimate those effects. a Timeline of MDMA or SAL treatment followed by Tcor measurement (day 1), fluorogold administration (FG; day 7) and tissue sectioning (day 14). b Immunohistochemical staining of tryptophan hydroxylase-2 (TpH2)-containing neurons in the DRN retrograded with FG. Photomicrographs show representative changes in FG-positive (FG+) or/and TpH2-positive (TpH2+) neurons in the DRN. The top row, the FG+ neurons; the middle row, the TpH2+ neurons; the bottom row, FG+/TpH2+. c Cell counts of FG+ and FG+/TpH2+ neurons (N = 4–6). **P < 0.01 vs. the SAL control, examined using unpaired t-test. CTL-S, saline as control; HD-H , high-dose-induced hypothermia; HD-H+, high-dose-induced hyperthermia; LD-H+, low-dose-induced hyperthermia

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