TY - JOUR AU - Shahid, Muhammad AU - Subhan, Fazal AU - Ahmad, Nisar AU - Sewell, Robert D. E. PY - 2019 DA - 2019/08/28 TI - Efficacy of a topical gabapentin gel in a cisplatin paradigm of chemotherapy-induced peripheral neuropathy JO - BMC Pharmacology and Toxicology SP - 51 VL - 20 IS - 1 AB - Chemotherapy induced peripheral neuropathy (CIPN) has been attributed to chemotherapeutic agents such as cisplatin which adversely affect disease outcome leading to increased cancer related morbidity. The clinical efficacy of systemic gabapentin in neuropathic pain management is limited by central side-effects in addition to a scarceness of conclusive evidence of its efficacy in CIPN management. The topical route therefore may provide a relatively safe alternative for neuropathic pain treatment in general and CIPN in particular. SN - 2050-6511 UR - https://doi.org/10.1186/s40360-019-0329-3 DO - 10.1186/s40360-019-0329-3 ID - Shahid2019 ER -