Fig. 1

Effect of topical gabapentin 10% gel (GBP-10%), topical control gel (CG) and systemic gabapentin at 75 mg/kg (GBP-75, i.p.) on the expression of cisplatin induced static allodynia [diminished von Frey filament threshold pressure (paw withdrawal threshold; PWT in g)] in hind paws after weekly intraperitoneal injection of cisplatin at 3.0 mg/kg (Cis-3) for four consecutive weeks in rats. Each symbol represents the mean PWT in g ± SEM. ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 as compared to the saline (Sal) alone treated control group, ^*P < 0.05, ^**P < 0.01, ^***P < 0.001 as compared to the cisplatin plus saline treated group, two-way repeated measures ANOVA followed by post hoc Bonferroni’s analysis; n = 6 rats per group