Fig. 3

Anti-hyperalgesic activities of poncirin in acute inflammatory pain model induced by carrageenan (a) inhibition of mechanical hyperalgesia, (b) inhibition of thermal hyperalgesia, (c) inhibition of mechanical allodynia and (d) reduction in paw thickness. Each column represents the mean ± SEM of 6–7 mice per group. *p < 0.05, **p < 0.01 and ***p < 0.001 denote the significant differences from the negative control group