Fig. 9

(a) Effect of treatment with poncirin on mRNA expression levels of TNF-α, (b) IL-6, (c) IL-1β and (d) VEGF in mice paw tissue. The mice were treated with poncirin (30 mg/kg, i.p), dexamethasone (5 mg/kg, i.p) or vehicle control as described in “Materials and methods”. Each column represents the mean ± SEM of 6–7 mice per group. *p < 0.05, ** p < 0.01 and ***p < 0.001 denote the significant differences from the negative control group