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Fig. 3 | BMC Pharmacology and Toxicology

Fig. 3

From: Chlorogenic acid protects PC12 cells against corticosterone-induced neurotoxicity related to inhibition of autophagy and apoptosis

Fig. 3

CGA suppressed CORT-induced autophagy in PC12 cells. a PC12 cells morphologies were observed by TEM, (Scale bar, 1 μm). b PC12 cells stained with Cyto-ID Green autophagy dye and analyzed by confocal microscopy. Untreated cells served as the vehicle control and cells treated with 50 nM rapamycin for 12 h served as the positive control, (Scale bar, 50 μm). c Changes in the expression of LC3 were examined by Western blot in PC12 cells (n = 3). d Densitometric values of LC3-II and LC3-I were quantified using the AlphaEaseFC software. Data are presented as mean ± SD. # P < 0.05, ## P < 0.01, ### P < 0.001 compared with the vehicle group. * P < 0.05, ** P < 0.01, *** P < 0.001 compared with the CORT group

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