TY - JOUR AU - Giordani, Camila F. A. AU - Campanharo, Sarah AU - Wingert, Nathalie R. AU - Bueno, Lívia M. AU - Manoel, Joanna W. AU - Costa, Barbara AU - Cattani, Shanda AU - Arbo, Marcelo Dutra AU - Garcia, Solange Cristina AU - Garcia, Cássia Virginia AU - Volpato, Nádia Maria AU - Schapoval, Elfrides Eva Scherman AU - Steppe, Martin PY - 2019 DA - 2019/12/19 TI - In vitro toxic evaluation of two gliptins and their main impurities of synthesis JO - BMC Pharmacology and Toxicology SP - 82 VL - 20 IS - 1 AB - The presence of impurities in some drugs may compromise the safety and efficacy of the patient’s treatment. Therefore, establishing of the biological safety of the impurities is essential. Diabetic patients are predisposed to tissue damage due to an increased oxidative stress process; and drug impurities may contribute to these toxic effects. In this context, the aim of this work was to study the toxicity, in 3 T3 cells, of the antidiabetic agents sitagliptin, vildagliptin, and their two main impurities of synthesis (S1 and S2; V1 and V2, respectively). SN - 2050-6511 UR - https://doi.org/10.1186/s40360-019-0354-2 DO - 10.1186/s40360-019-0354-2 ID - Giordani2019 ER -