|
Premenopausal (n = 20)
|
Postmenopausal (n = 20)
| |
---|
AUCτ (ng*h/mL)
|
Geometric Mean
|
95% CI
|
Geometric Mean
|
95% CI
|
P-value
|
---|
TAM
|
2806.78
|
2128.19
|
3701.75
|
4829.41
|
4244.20
|
5495.30
|
< 0.001
|
NDTAM
|
11,643.86
|
8132.88
|
16,670.55
|
20,253.09
|
17,886.43
|
22,932.88
|
< 0.010
|
4-HTAM
|
61.67
|
44.15
|
86.15
|
112.23
|
98.75
|
127.55
|
< 0.001
|
END
|
192.14
|
111.75
|
330.35
|
452.77
|
355.65
|
576.40
|
0.013
|
Css (ng/mL)
|
TAM
|
116.95
|
88.67
|
154.24
|
201.23
|
176.84
|
228.97
|
< 0.001
|
NDTAM
|
485.16
|
338.87
|
694.61
|
843.88
|
745.27
|
955.54
|
< 0.010
|
4-HTAM
|
2.57
|
1.84
|
3.59
|
4.68
|
4.11
|
5.31
|
< 0.001
|
END
|
8.01
|
4.66
|
13.76
|
18.87
|
14.82
|
24.02
|
0.013
|
Metabolic Ratios
|
TAM/NDTAM
|
0.20
|
0.15
|
0.26
|
0.21
|
0.19
|
0.23
|
0.523
|
TAM/4-HTAM
|
46.27
|
36.67
|
58.39
|
38.12
|
31.79
|
45.70
|
0.177
|
NDTAM/END
|
68.98
|
46.26
|
102.86
|
44.35
|
32.78
|
60.01
|
0.230
|
4-HTAM/END
|
0.30
|
0.20
|
0.44
|
0.24
|
0.19
|
0.31
|
0.275
|
Apparent clearance (L/h)
|
TAM
|
7.13
|
5.40
|
9.40
|
4.14
|
3.64
|
4.71
|
0.015
|
- Tamoxifen (TAM), endoxifen (END), 4-hydroxytamoxifen (4-HTAM) and N-desmethyl tamoxifen (NDTAM)