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Table 3 Frequencies of CYP2D6 and CYP3A gene variants in the investigated TAM-treated breast cancer patients (n = 40)

From: Hormonal status affects plasma exposure of tamoxifen and its main metabolites in tamoxifen-treated breast cancer patients

Gene Premenopausal (n = 20)Postmenopausal (n = 20)
CYP2D6
 Activity scoreFunctionFrequencies of gene variants
  0PM00
  0.5IM0.150
  1Slow NM0.300.2
  1.5NM0.250.35
  2NM0.250.35
   > 2UM00
 others0.050.10
CYP3A5
 *3Variant  
 AA (*3/*3)0.650.7
 AG (*3/*1)0.350.2
 GG (*1/*1)00.1
CYP3A4
 *1bVariant  
 AA (*1/*1)0.80.7
 AG (*1/*1b)0.20.3
 GG (*1b/*1b)00
 *22Variant  
 CC (*1/*1)0.90.95
 CT (*1/*22)0.10.05
 TT (*22/*22)00