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Table 1 Characteristics of included studies

From: Antihistamine effects and safety of fexofenadine: a systematic review and Meta-analysis of randomized controlled trials

First author, YearsStudy designSubjectNumberExperimentalComparatorsStudy durationOutcome measures
Barbanoj [25], 2003RCT, crossover studyhealthy18FEX 120 mg
n = 18
EBA 20 mg..
n = 18;
PL n = 18
5 daysWheal, flare, AE, sedative effects
Boyle [36], 2005RCT, crossover studyhealthy18FEX 60 mg,
n = 18
LOR 10 mg,
n = 18;
PL n = 18
2 monthsWheal, flare, AE, sedative effects
Larbig [57], 2006RCT, crossover studyhealthy30FEX 120 mg,
n = 30
PL n = 3024 hWheal, flare
Simons [55], 2002RCT, parallel studyhealthy21FEX 180 mg,
n = 7
CHL 8 mg,
n = 7;
LOR 10 mg,
n = 7
9 daysWheal, flare
Simons [31], 2003RCT, crossover studyhealthy15FEX 30 mg,
n = 15
CET 10 mg,
n = 15
24 hWheal, flare, sedative effects
Takahashi [56], 2004RCT, crossover studyhealthy7FEX 120 mg,
n = 7
BEP 20 mg,
n = 7;
PL n = 7
24 hWheal, flare, VAS of drowsiness
Finn [11], 1999RCT, parallel studyCIU439FEX 40 mg/ 120 mg/240 mg/480 mg,
n = 349
PL n = 904 weeksAE, sedative effects
Berger [41], 2006RCT, parallel studyAR432FEX 180 mg,
n = 288
PL n = 14415 daysAE, sedative effects
Berkowitz [42], 2006RCT, crossover studyAR63FEX 180 mg,
n = 63
PL n = 632 weeksAE, sedative effects
Boyle [43], 2006RCT, crossover studyhealthy18FEX 120 mg,
n = 18
CHL 6 mg, n = 18;
PL n = 18
10 hAE, sedative effects
Bronsky [10], 1998RCT, parallel studyAR548FEX 80 mg/ 120 mg/ 240 mg,
n = 411
PL n = 13714 daysAE, sedative effects
Casale [13], 1999RCT, parallel studyAR861FEX 120 mg/ 180 mg,
n = 569
PL n = 2923 weeksAE, sedative effects
Van Cauwenberge [17], 2000RCT, parallel studyAR685FEX 120 mg, n = 232LOR 10 mg,
n = 228;
PL n = 225
14 daysAE, sedative effects
Day [33], 2004RCT, parallel studyAR575FEX 180 mg, n = 239CET 10 mg,
n = 240;
PL n = 96
24 hAE, sedative effects
Ramesh [50], 2013RCT, parallel studyAR50FEX 120 mg, n = 25CHL 4 mg,
n = 25
14 daysAE, sedative effects
Grant [14], 1999RCT, crossover studyhealthy14FEX 60 mg,
n = 14
CET 10 mg,
n = 14;
EPI 20 mg,
n = 14;
TER 60 mg,
n = 14;
LOR 10 mg,
n = 14;
PL n = 14
24 hAE, sedative effects
Grant [23], 2002RCT, crossover studyhealthy18FEX 180 mg, n = 18EBA 10 mg,
n = 18;
LOR 10 mg,
n = 18;
MIZ 10 mg,
n = 18;
PL n = 18
24 hAE, sedative effects
Hampel [26], 2003RCT, parallel studyAR495FEX 180 mg, n = 248CET 10 mg, n = 2472 weeksAE, sedative effects
Hampel [45], 2007RCT, parallel studyAR393FEX 30 mg/ 60 mg,
n = 193
PL n = 2008 daysAE, sedative effects
Hashiguchi [52], 2016RCT, crossover studyhealthy126FEX 120 mg, n = 126BIL 10 mg/
20 mg,
n = 252;
PL n = 126
3 daysAE, sedative effects
Hindmarch [24], 2002RCT, crossover studyhealthy15FEX 360 mg, n = 15PRO 30 mg n = 15,
PL n = 15
7 hAE, sedative effects, CFF, CRT, LARS
Hindmarch [15], 1999RCT, crossover studyhealthy24FEX 120 mg, n = 24PRO 30 mg,
n = 24;
LOR 10 mg,
n = 24;
PL n = 24
24 hAE, sedative effects, CFF, CRT, LARS
Horak [20], 2001RCT, crossover studyAR40FEX 120 mg, n = 40CET 10 mg,
n = 40;
PL n = 40
2 daysAE, sedative effects
Horak [48], 2010RCT, crossover studyallergic volunteers75FEX 120 mg, n = 70CET 10 mg,
n = 68;
BIL 20 mg,
n = 74;
PL n = 70
2 daysAE, sedative effects
Horak [34], 2005RCT, crossover studyallergic volunteers94FEX 120 mg, n = 94PL n = 942 daysAE, sedative effects
Howarth [16], 1999RCT, parallel studyAR722FEX 120 mg/ 180 mg, n = 421CET 10 mg,
n = 209;
PL n = 209
2 weeksAE, sedative effects
Inami [53], 2016RCT, crossover studyhealthy20FEX 60 mg,
n = 20
DIP 50 mg,
n = 20;
PL n = 20
6 hAE, sedative effects, LARS
Kaiser [47], 2008RCT, parallel studyAR835FEX 120 mg, n = 359LOR 10 mg,
n = 357;
PL n = 119
7 daysAE, sedative effects
Kaiser [21], 2001RCT, parallel studyAR836FEX 120 mg, n = 360LOR 10 mg,
n = 357;
PL n = 119
7 daysAE, sedative effects
Kamei [49], 2012RCT, crossover studyhealthy24FEX 60 mg,
n = 24
PRO 25 mg,
n = 24;
OLO 5 mg,
n = 24;
PL n = 24
8 hAE, sedative effects, CFF, CRT, LARS
Kamei [28], 2003RCT, crossover studyhealthy11FEX 120 mg, n = 11d-CHL 4 mg,
n = 11;
OLO 10 mg,
n = 11;
PL n = 11
8 hAE, sedative effects, CFF, CRT, CTT, LARS
Mansfield [29], 2003RCT, crossover studyhealthy42FEX 180 mg, n = 42DIP 50 mg,
n = 42;
PL n = 42
2 hAE, sedative effects
Milgrom [46], 2007RCT, parallel studyAR453FEX 60 mg,
n = 222
PL n = 2312 weeksAE, sedative effects
Okubo [44], 2006RCT, crossover studyhealthy9FEX 60 mg, n = 9EPI 20 mg,
n = 9;
PL n = 9
5 hAE, sedative effects
Okubo [54], 2016RCT, parallel studyAR747FEX 120 mg, n = 247BIL 20 mg,
n = 249;
PL n = 251
2 weeksAE, sedative effects
Prenner [18], 2000RCT, crossover studyAR929FEX 120 mg, n = 457LOR 10 mg,
n = 472
14 daysAE, sedative effects
Purohit [22], 2001RCT, crossover studyhealthy26FEX 120 mg/ 180 mg, n = 52CET 10 mg,
n = 26;
PL n = 26
24 hAE, sedative effects
Purohit [35], 2004RCT, crossover studyhealthy42FEX 180 mg, n = 42CET 10 mg,
n = 42
4 hAE, sedative effects
Ridout [30], 2003RCT, crossover studyhealthy18FEX 180 mg, n = 18HYD 50 mg,
n = 18;
PL n = 18
5 hAE, sedative effects, CFF, CRT, LARS
Schapowal [39], 2005RCT, parallel studyAR220FEX 180 mg, n = 113PL n = 10714 daysAE, sedative effects
Schoepke [51], 2013RCT, crossover studyhealthy18FEX 120 mg, n = 18PL n = 1824 hAE, sedative effects
Simons [9], 1997RCT, crossover studyhealthy20FEX 120 mg, n = 40LOR 10 mg,
n = 20
PL n = 20
24 hAE, sedative effects
Tsuda [40], 2005RCT, crossover studyhealthy10FEX 120 mg, n = 10CET 5 mg/10 mg,
n = 20;
LOR 10 mg,
n = 10;
PL n = 10
24 hAE, sedative effects
Wahn [32], 2003RCT, parallel studyAR935FEX 30 mg,
n = 464
PL n = 47114 daysAE, sedative effects
Weiler [19], 2000RCT, crossover studyhealthy40FEX 60 mg,
n = 40
DIP 50 mg,
n = 40;
PL n = 40
5 hAE, sedative effects, VAS of drowsiness
Ballmer-Weber [12], 1999RCT, crossover studyhealthy20FEX 180 mg, n = 20CET 10 mg,
n = 40;
ACR 8 mg,
n = 20
1 hsedative effects
Day [37], 2005RCT, parallel studyAR599FEX 180 mg, n = 250CET 10 mg,
n = 249;
PL n = 100
7 hsedative effects
Handa [27], 2004RCT, parallel studyCIU97FEX 180 mg, n = 45CET 10 mg,
n = 52
28 dayssedative effects
Hyo [38], 2005RCT, parallel studyhealthy113FEX 120 mg, n = 28CET 10 mg,
n = 30;
LOR 10 mg,
n = 28;
PL n = 27
2 dayssedative effects
Ridout [58], 2002RCT, crossover studyhealthy24FEX 120 mg, n = 24PRO 25 mg,
n = 24;
PL n = 24
8 hCFF, CRT, CTT, LARS
Naicker [59], 2013RCT, crossover studyhealthy11FEX 180 mg, n = 11PRO 25 mg, n = 11; LOR 10 mg,
n = 11;
PL n = 11
3 hCRT, CTT, VAS of drowsiness