Table 3 Overall ADR reports collected from FAERS, AIFA and Yellow Card Scheme Databases in 1999–2018
Antibiotics | 1999–2008a | 2009–2018d | p value |
|---|---|---|---|
Colistin | |||
 FAERS (mean per year ± SD) | 8.1 ± 9.6 | 70.2 ± 51.4 | 0.00402 |
 AIFA (mean per year ± SD) | 0.4 ± 0.8 | 12.6 ± 9.3 | 0.0025 |
 Yellow Card Scheme (mean per year ± SD) | 1.7 ± 3.3 | 7.0 ± 3.0 | 0.0015 |
Gentamicin | |||
 FAERS (mean per year ± SD) | 178 ± 70.5 | 356.2 ± 176.3 | 0.0119 |
 AIFA (mean per year ± SD) | 6.1 ± 4.3 | 22.9 ± 6.7 | < 0.001 |
 Yellow Card Scheme (mean per year ± SD) | 11.5 ± 4.5 | 29.2 ± 16.2 | 0.00732 |
Meropenem | |||
 FAERS (mean per year ± SD) | 96.5 ± 46.9 | 504.8 ± 304.9 | 0.00214 |
 AIFA (mean per year ± SD) | 5.6 ± 2.9 | 45.5 ± 17.7 | < 0.001 |
 Yellow Card Scheme (mean per year ± SD) | 9.3 ± 4.3 | 35.2 ± 9.7 | < 0.001 |
Tigecyclin | |||
 FAERSb (mean per year ± SD) | 101.3 ± 56.5 | 147.4 ± 40.6 | 0.21 |
 AIFAc(mean per year ± SD) | 0.7 ± 1.2 | 13.3 ± 6.3 | < 0.001 |
 Yellow Card Schemec(mean per year ± SD) | 10 ± 5.3 | 6.3 ± 3.5 | 0.35 |
Ceftazidime-Avibactamd | |||
 FAERS (mean per year ± SD) | – | 53.3 ± 37.9 | – |
 AIFA (mean per year ± SD) | – | 7.67 ± 4.5 | – |
 Yellow Card Scheme (mean per year ± SD) | – | 7 ± 4.24 | – |