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Table 2 Average change in urges-to-smoke scores between the 6 mg and 4 mg nicotine gum

From: Effect of nicotine 6 mg gum on urges to smoke, a randomized clinical trial

TimeAverage score change from baseline (mm)
 Gum 6 mg (n = 232)Gum 4 mg (n = 236)6 mg vs 4 mg
3 min−7.2 ± 9.0−6.1 ± 8.7−1.1 [− 2.2, − 0.1], p = 0.034
5 min−12.2 ± 13.4− 10.4 ± 12.9−1.9 [− 3.4, − 0.4], p = 0.016
10 min−21.8 ± 18.6−18.7 ± 17.5−3.1 [− 5.0, − 1.2], p < 0.001
1 h− 43.9 ± 23.8−39.3 ± 23.3−4.8 [− 7.0, − 2.6], p < 0.001a
2 h− 42.7 ± 23.6− 38.7 ± 23.7− 4.2 [− 6.2, − 2.1], p < 0.01
3 h− 38.8 ± 23.2− 35.5 ± 23.4−3.4 [− 5.8, − 1.0], p = 0.004a
4 h− 33.9 ± 22.6− 31.1 ± 22.7− 2.9 [− 5.0, − 0.7], p = 0.008
5 h− 28.7 ± 21.8−26.3 ± 21.5− 2.5 [− 4.6, − 0.4], p = 0.021
  1. aEstimate [97.5% CI] and Bonferroni adjusted p-value. Estimated mean (±SD) average changes in urges-to-smoke scores over 3, 5 and 10 min and 1, 2, 3, 4 and 5 h following administration of 6 mg gum or 4 mg gum, and corresponding comparisons between treatments (estimated treatment difference [95% CI] and p-value)