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Fig. 2 | BMC Pharmacology and Toxicology

Fig. 2

From: KEA-1010, a ketamine ester analogue, retains analgesic and sedative potency but is devoid of Psychomimetic effects

Fig. 2

KEA-1010 hydrolysis is more rapid when exposed to CES1b expressing Supersomes in vitro. KEA-1010 concentration (as percent of time zero) following incubation with CES1b and CES2 expressing Supersomes in vitro (a), and: accumulation of the compound’s carboxylic acid metabolite (KEA-1025) in the same incubations (b), confirming that rapid degradation of the parent ester is largely by CES-1 type enzymes, found predominantly in the liver

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