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Fig. 5 | BMC Pharmacology and Toxicology

Fig. 5

From: KEA-1010, a ketamine ester analogue, retains analgesic and sedative potency but is devoid of Psychomimetic effects

Fig. 5

KEA-1010 attenuates post incisional mechanical allodynia; synergy with fentanyl. Pedal withdrawal threshold following hindpaw incision and suture under isoflurane anaesthesia augmented with fentanyl 10 μg/kg (a), KEA-1010 20 mg/kg (b), or fentanyl 10 μg/kg and KEA-1010 20 mg/kg in rats (c & d). Weight bearing status at 60 min (e), and 360 min (f) following surgery. Data mean (SEM). *P < 0.05, **p < 0.01, ***P < 0.001 (Bonferroni). N = 7 all groups

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