Fig. 6From: KEA-1010, a ketamine ester analogue, retains analgesic and sedative potency but is devoid of Psychomimetic effectsTolerance to morphine analgesia in rat tail flick latency. Development of tolerance to thermal tail flick stimuli following continuous subcutaneous pump administration of morphine (6 mg/day) in rats take 3–4 days. Data mean (SEM). ***P < 0.001 (Bonferroni). N = 18 all groupsBack to article page