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Table 1 Behavioural dysfunction scoring

From: KEA-1010, a ketamine ester analogue, retains analgesic and sedative potency but is devoid of Psychomimetic effects

1) General Exopthalmos
Increased respiration
Decreased respiration
2) Motor Subdued
Increased/decreased body tone
Increased/decreased locomotor activity
3) Reactivity Increased irritability on gentle handling
Decreased irritability on gentle handling
Rearing
4) Stereotypical behaviours Head weaving
Ataxia/decreased co-ordination
Splayed hind legs
  1. A score of 1 or zero is allowed for each of the four categories permitting a maximum score of four
  2. (Modified from Koros et al. 2007 [53])
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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