Table 3 Molecular target binding profiles
Molecular Target (Assay Type) | Ketamine | KEA-1010 | KEA-1025 |
|---|---|---|---|
IC50 [Percent Inhibition at 10 μM] | |||
Ca2+ Channel L-Type (Radioligand Binding) | >  10 μM [24%] | >  10 μM [−] | >  10 μM [−] |
GABAA Receptor (Radioligand Binding) | >  10 μM [−] | >  10 μM [−] | >  10 μM [−] |
δ1 Opiate Receptor (Radioligand Binding) | >  10 μM [−] | >  10 μM [−] | >  10 μM [−] |
μ Opiate Receptor (Radioligand Binding) | >  10 μM [−] | >  10 μM [−] | >  10 μM [−] |
Norepinephrine Uptake Site (Functional Uptake Assay) | >  10 μM [23%] | >  10 μM [−] | >  10 μM [−] |
HCN1 K+ Channel (Patch-Clamp Functional Assay) | >  100 μM [15%] | >  100 μM [20%] | >  100 μM [−] |