Table 1 Pharmacokinetic parameters of metoclopramide after an oral administration of metoclopramide (0.5 mg/kg) to rabbits in the presence and absence of Cola nitida (mean ± SEM, n = 5). *P < 0.05, compared to the control given metoclopramide alone. Tmax (hr) = time to reach peak blood concentration; Cmax (ng/mL) = peak blood concentration; AUC0-7 h (ng/h/mL) = area under the blood concentration time curve; Ka (hr-1) = absorption rate constant; CL (L/hr./kg) = clearance rate; T1/2 = Half-life; Kel = elimination rate constant
AUC0-7 h ng/h/mL) | Tmax hr) | Cmax (ng/mL) | Ka (hr-1) | CL L/hr./kg) | T ½ hr) | Kel (hr-1) | |
|---|---|---|---|---|---|---|---|
MCP | 1688.2 ± 112.2 | 1.5 ± 0.03 | 280 ± 15.30 | 0.80 ± 0.01 | 0.56 ± 0.01 | 4.5 ± 0.05 | 0.15 ± 0.02 |
MCP + K | 821.06 ± 61.4* | 2+ 0.03 | 171.49 ± 23.50 | 0. 72 ± 0.05 | 1.11 ± 0.03 | 2.2 ± 0.05* | 0.32 ± 0.02 |
% Change from control | −51 | 33 | −39 | −10 | 98 | −51 | 113 |