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Table 1 Pharmacokinetic parameters of metoclopramide after an oral administration of metoclopramide (0.5 mg/kg) to rabbits in the presence and absence of Cola nitida (mean ± SEM, n = 5). *P < 0.05, compared to the control given metoclopramide alone. Tmax (hr) = time to reach peak blood concentration; Cmax (ng/mL) = peak blood concentration; AUC0-7 h (ng/h/mL) = area under the blood concentration time curve; Ka (hr-1) = absorption rate constant; CL (L/hr./kg) = clearance rate; T1/2 = Half-life; Kel = elimination rate constant

From: The effects of oral administration of Cola nitida on the pharmacokinetic profile of metoclopramide in rabbits

 AUC0-7 h ng/h/mL)Tmax hr)Cmax (ng/mL)Ka (hr-1)CL L/hr./kg)T ½ hr)Kel (hr-1)
MCP1688.2 ± 112.21.5 ± 0.03280 ± 15.300.80 ± 0.010.56 ± 0.014.5 ± 0.050.15 ± 0.02
MCP + K821.06 ± 61.4*2+  0.03171.49 ± 23.500. 72 ± 0.051.11 ± 0.032.2 ± 0.05*0.32 ± 0.02
% Change from control−5133−39−1098−51113