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Table 1 Indole derivatives with MetK inhibition potential in all pathogens under study

From: Prospects of Indole derivatives as methyl transfer inhibitors: antimicrobial resistance managers

Zinc IdsNg
−8.7*
Ab
−7.2*
Cc
−6.4*
Kp
− 6.2*
Ef
−5.6*
Hp
−4.7*
Pa
− 6.0*
Sa
− 6.1*
St
− 6.1*
ZINC04899565−10.4−7.7−8.3− 7.4−6.9−5.3− 6.9−6.7− 7.3
ZINC15219763−9.5−7.5− 9.8−8.3− 7.1− 6.1−7.8−6.9− 7.5
ZINC49171024−10.8−7.6− 7.9−7.4− 6.9− 5.6−7.8− 6.9−7.0
  1. *Binding energy of native ligand
  2. Ng: Neisseria gonorrhoeae; Ab: Acinetobacter baumannii; Cc: Campylobacter coli; Kp: Klebsiella pneumoniae; Ef: Enterococcus faecium; Hp: Helicobacter pylori; Pa: Pseudomonas aeruginosa; Sa: Staphylococcus aureus; St: Salmonella typhi.