Prospects of Indole derivatives as methyl transfer inhibitors: antimicrobial resistance managers

Table 2 Indole derivatives with Dam inhibition potential in all pathogens under study

Zinc Ids	Ng − 6.8*	Ab −8.3*	Cc − 8.2*	Kp − 7.5*	Ef −6.6*	Hp − 8.0*	Pa	Sa − 8.7*	St − 8.6*
ZINC04899565	−7.7	− 9.2	− 9.5	− 9.4	− 6.9	−8.1	#	−9.6	− 9.5
ZINC49171024	−8.5	−9.5	− 10.1	−9.3	− 8.0	−8.9	#	−10.0	− 9.5

*Binding energy of native ligand
# B. E not calculated due to unavailability of valid 3D structure.
Ng: Neisseria gonorrhoeae; Ab: Acinetobacter baumannii; Cc: Campylobacter coli; Kp: Klebsiella pneumoniae; Ef: Enterococcus faecium; Hp: Helicobacter pylori; Pa: Pseudomonas aeruginosa; Sa: Staphylococcus aureus; St: Salmonella typhi.

ISSN: 2050-6511