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Table 2 Indole derivatives with Dam inhibition potential in all pathogens under study

From: Prospects of Indole derivatives as methyl transfer inhibitors: antimicrobial resistance managers

Zinc IdsNg
− 6.8*
Ab
−8.3*
Cc
− 8.2*
Kp
− 7.5*
Ef
−6.6*
Hp
− 8.0*
PaSa
− 8.7*
St
− 8.6*
ZINC04899565−7.7− 9.2− 9.5− 9.4− 6.9−8.1#−9.6− 9.5
ZINC49171024−8.5−9.5− 10.1−9.3− 8.0−8.9#−10.0− 9.5
  1. *Binding energy of native ligand
  2. # B. E not calculated due to unavailability of valid 3D structure.
  3. Ng: Neisseria gonorrhoeae; Ab: Acinetobacter baumannii; Cc: Campylobacter coli; Kp: Klebsiella pneumoniae; Ef: Enterococcus faecium; Hp: Helicobacter pylori; Pa: Pseudomonas aeruginosa; Sa: Staphylococcus aureus; St: Salmonella typhi.