TY - JOUR AU - Chen, Mengchun AU - Sun, Wei AU - Wang, Zhe AU - Huang, Chengke AU - Hu, Guoxin AU - Chen, Yijie AU - Wang, Ledan PY - 2020 DA - 2020/04/07 TI - Determination of parecoxib and valdecoxib in rat plasma by UPLC-MS/MS and its application to pharmacokinetics studies JO - BMC Pharmacology and Toxicology SP - 27 VL - 21 IS - 1 AB - The present study aimed to develop and validate a rapid, selective, and reproducible ultra-performance liquid chromatography-tandem mass spectrometry separation method for the simultaneous determination of the levels of parecoxib and its main metabolite valdecoxib in rat plasma. Moreover, this method was applied to investigate the pharmacokinetics of parecoxib and valdecoxib in rats. SN - 2050-6511 UR - https://doi.org/10.1186/s40360-020-00406-5 DO - 10.1186/s40360-020-00406-5 ID - Chen2020 ER -