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Table 3 Stability of parecoxib, valdecoxib and celecoxib (IS) under various conditions (n = 6)

From: Determination of parecoxib and valdecoxib in rat plasma by UPLC-MS/MS and its application to pharmacokinetics studies

CompoundConcentration (ng/mL)Short-term (room temperature, 24 h)Long-term (−20 °C, 3 weeks)Freeze/thaw (−20 °C to room temperature)
RSD(%)RE(%)RSD(%)RE(%)RSD(%)RE(%)
 10012.213.012.914.212.814.9
Parecoxib8005.210.211.112.78.414.2
 80006.5−10.56.114.313.4−7.9
 510.6−6.713.2−1.414.95.2
Valdecoxib407.6127.513.28.414.2
 4005.93.27.73.279.5
Celecoxib2004.27.55.2−1.35.25.8