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Table 4 Pharmacokinetics parameters of the parecoxib and valdecoxib after sublingual vein administration of 5 mg/kg PCX in rat (n = 6)

From: Determination of parecoxib and valdecoxib in rat plasma by UPLC-MS/MS and its application to pharmacokinetics studies

ParameterParecoxibValdecoxib
AUC(0-t)(ug/L*h)2106.8 ± 282.34186.1 ± 1593.0
AUC(0-∞)(ug/L*h)2108.0 ± 282.64371.7 ± 1526.3
MRT(0-t)(h)0.4 ± 0.14.1 ± 1.0
MRT(0-∞)(h)0.4 ± 0.14.8 ± 1.1
t1/2(h)1.4 ± 0.53.1 ± 1.1
Tmax(h)0.1 ± 0.00.8 ± 0.2
CL(L/h/kg)2.4 ± 0.31.2 ± 0.4
Cmax (ug/L)5066.4 ± 1207.9700.6 ± 92.6