Table 4 Pharmacokinetics parameters of the parecoxib and valdecoxib after sublingual vein administration of 5 mg/kg PCX in rat (n = 6)

AUC(0-t)(ug/L*h)

2106.8 ± 282.3

4186.1 ± 1593.0

AUC(0-∞)(ug/L*h)

2108.0 ± 282.6

4371.7 ± 1526.3

MRT(0-t)(h)

0.4 ± 0.1

4.1 ± 1.0

MRT(0-∞)(h)

0.4 ± 0.1

4.8 ± 1.1

t_1/2(h)

1.4 ± 0.5

3.1 ± 1.1

Tmax(h)

0.1 ± 0.0

0.8 ± 0.2

CL(L/h/kg)

2.4 ± 0.3

1.2 ± 0.4

Cmax (ug/L)

5066.4 ± 1207.9

700.6 ± 92.6